陕西医学杂志Issue(1)：52-55,4.DOI:10.3969/j.issn.1000-7377.2014.01.018
β细胞素基因多态性与2型糖尿病患者血脂异常相关性研究
The correlation between betacellulin gene polymorphism and dyslipidemia in type 2 diabetes mellitus
于俊霞 1李秀丽 1杨渭临1
作者信息
- 1. 西安交通大学医学院第二附属医院干三病区 西安710004
- 折叠
摘要
Abstract
Objective:To screen single nucleotide polymorphyisms of BTC exon 1 TGC19GGC and 5′UTR A-226G and to analyze the correlation between BTC gene SNPs and Dyslipidemia .Methods :All T2 DM patients were consisted of 130 persons ,Normal control group were consisted 96 persons ;Screened SNP of the exon 1 TGC19GGC by RFLP-PCR ,Screened SNP of the A-226G by SASP-PCR .Results :①The exon 1 TGC19 GGC mutation :TC、TG、LDL-C、HDL-C were no significant differences between TG genotype and TT genotype in T2DM group(P>0 .05);TC、TG、LDL-C were no significant differences between TG genotype and TT genotype in normal control group (P>0 .05);The level of HDL-c in blood was lower in TG genotype than in TT genotype in normal control group(P>0 . 05) .②The 5′UTR A-226G mutation :TC、TG、LDL-C、HDL-C were no significant differences between two geno-types in T2 DM group(P>0 .05);TC、HDL-C、LDL-C were no significant differences between two genotypes in nor-mal control group (P>0 .05);The level of TG in blood was higher in GG genotype in normal control group (P<0 . 05) .Conclusion:①In the study of BTC exon 1 TGC19 GGC ,the site SNP is not correlated with Dyslipidemia in T2 DM group ;the TG genotype is correlated with the level of HDL-c in blood in normal control group .②In the study of BTC 5′UTR A-226G ,the site SNP is not correlated with Dyslipidemia in T2DM group ;the GG genotype is signifi-cantly correlated with the level of TG in blood in normal control group .关键词
糖尿病 ,非胰岛素依赖型/血液/甘油三酯类/代谢/脂蛋白类,HDL/代谢/胆固醇/代谢/β细胞素/多态性Key words
Diabetes mellitus ,non-insulin-dependent/blood/Triglycerides/metablism/Lipoproteins , HDL/metablism/Cholesterol/metablism/Beta cellulin gene/polymorphism分类
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于俊霞,李秀丽,杨渭临..β细胞素基因多态性与2型糖尿病患者血脂异常相关性研究[J].陕西医学杂志,2014,(1):52-55,4.
