陕西医学杂志Issue(1)：66-67,2.DOI:10.3969/j.issn.1000-7377.2014.01.023
良恶性乳腺疾病动态增强MRI表现特征与血管生成相关性研究
Benign and malignant breast lesions characteristic dynamic contrast enhanced MRI correlation with angiogenesis preliminary study
摘要
Abstract
Objective:To investigate the analysis of benign and malignant breast lesions characteristic dy-namic contrast enhanced MRI and vascular endothelial growth factor expression levels as well as the correlation be-tween microvessel density .Methods :The subjects were 40 patients in our hospital dynamic enhanced MRI breast examination and also by pathological and immunohistochemical diagnosis of patients .Through early enhancement ra-tio ,time-signal intensity curve ,peak enhancement evaluate the performance of dynamic contrast-enhanced M RI ;pathology associated antigens by immunohistochemistry ,and serum vascular endothelial grow th factor expression and microvessel density .Results :40 cases of breast disease ,malignant lesions in 24 patients ,16 patients with be-nign lesions and malignant lesions of the vascular endothelial growth factor expression and microvessel density were significantly higher than benign lesions ,the difference (P <0 .05) ,with statistical significance .40 cases of benign and malignant breast disease patients ,early enhancement rate> 60% of patients with early enhancement rate <60%of patients compared with time-signal intensity curve ,and vascular endothelial growth factor in the difference be-tween the expression levels (P> 0 .05 ) ,was not statistically significant ;while peak enhancement ,the difference between microvessel density (P <0 .05) ,with statistical significance .Conclusion:benign and malignant breast le-sions characteristic dynamic contrast enhanced MRI and vascular endothelial growth factor expression and microves-sel density levels are closely related .关键词
乳腺疾病/病理学/乳腺疾病/诊断/内皮 ,血管/代谢/生长物质/代谢/磁共振成像/微血管密度Key words
Breast diseases/pathology/Breast diseases/diagnosis/Endothelium ,vascular/metablism/Growth substances/metablism/Magnetic resonance imaging/Microvessel density分类
医药卫生引用本文复制引用
冯锦兰,刘鸿圣..良恶性乳腺疾病动态增强MRI表现特征与血管生成相关性研究[J].陕西医学杂志,2014,(1):66-67,2.基金项目
广东省自然科学基金 S2012040007285 （）
