实用肝脏病杂志Issue(5)：407-410,4.DOI:10.3969/j.issn.1672-5069.2013.05.008
血清高尔基体蛋白73诊断肝细胞癌价值探讨
The accuracy of serum golgi protein-73 le vels in diagnosis of patients with hepatocellular carcinoma
郑联坵 1魏开鹏 1潘兴南 1魏梅娟 1张小曼 1王崇国1
作者信息
- 1. 362000 福建省泉州市 解放军第180医院肝病中心
- 折叠
摘要
Abstract
Objective To explore the accuracy of serum golgi protein-73 levels in diagnosis of patients with hepatocellular carcinoma (HCC). Methods 400 patients with HCC,200 with liver cirrhosis (LC),100 with chronic hepatitis B(CHB)and 100 healthy controls(HC)were collected in this study. Enzyme linked immunosorbent assay and electrochemiluminescence immunoassay were used to detect serum GP-73 and alpha fetal protein (AFP),respectively. The ability of GP73 and AFP in diagnosis of patients with HCC was evaluated by the area under the receiver operating characteristic curves (AUROC). Results Serum GP73 levels in patients with HCC, CHB and LC were 243.6±163.1ng/ml,85.6±35.3ng/ml and 81.9±36.4ng/ml,respectively,all of which were significantly higher than that in HC (78.2±33.9ng/ml,P<0.05);The optimal cut-off value of GP-73 and AFP for diagnosis of HCC were 150.7ng/ml and 19.7ng/ml,respectively and the AUROC of GP73 was 0.846,with a sensitivity of 69.2%and a specificity of 90.5%,which were both better than AFP(0.828,57.6% and 88.1%,respectively,P<0.05);When GP73 in combination with AFP,they led to an enhanced sensitivity of HCC detection up to 73.5% and the AUROC was 0.887;There was no difference in the positive rate of GP-73 between AFP positive or negative HCC subjects. Conclusion Serum GP-73 has a better accuracy than AFP for the diagnosis of HCC,and serum GP73 in com-bination with AFP might further increase the accuracy for HCC diagnosis.关键词
肝细胞癌/高尔基体蛋白73/甲胎蛋白/诊断Key words
Hepatocellular carcinoma/Golgi protein-73/Alpha-fetoprotein/Diagnosis引用本文复制引用
郑联坵,魏开鹏,潘兴南,魏梅娟,张小曼,王崇国..血清高尔基体蛋白73诊断肝细胞癌价值探讨[J].实用肝脏病杂志,2013,(5):407-410,4.
