实用肝脏病杂志Issue(6)：499-501,3.DOI:10.3969/j.issn.1672-5069.2013.06.007
非酒精性脂肪性肝病与心血管疾病的相关性分析
Cardiovascular disease in patients with non-alcoholic fatty liver disease
摘要
Abstract
Objective To investigate the risk factors of cardiovascular disease in patients with nonalcoholic fatty liver disease (NAFLD). Methods Forty-eight patients with NAFLD and forty-three healthy persons were in-cluded in this study. The NAFLD was diagnosed by computed tomography. Ultrasound was taken for intimal medi-al thickness (IMT)and carotid atherosclerotic plaque examination. The clinical and biochemical features,endothelial function and coronary atherosclerotic plaque examination were also analyzed. Results The levels of sICM-1,ET-1 and baPWV in NAFLD group(185.1±36.2)ng/ml,(104.8±19.3)pg/ml and(15.5±2.3)cm/s were higher than those (85.4±17.3)ng/ml,(67.5±12.1)pg/ml and (13.6±2.4)cm/s,(P<0.05),while the FMD level (8.1±2.4)%was lower than that (13.2±3.5%),(P<0.05)in the healthy persons;In addition,the IMT (1.31±0.35)mmand the prevalence of patches in carotid(31.3%)and in coronary artery(35.4%)in patients with NAFLD increased than in healthy per-sons (0.76±0.18)mm,9.3% and 11.6%,(P<0.05). Conclusion NAFLD is closely associated with cardiovascular disease. The patients with NAFLD might have vascular endothelial dysfunction,and they might be checked-up for early evaluation of vascular atherosclerosis.关键词
非酒精性脂肪性肝病/心血管疾病/内皮功能/粥样硬化Key words
Nonalcoholic fatty liver disease/Cardiovascular disease/Endothelial function/Atherosclerosis引用本文复制引用
王军,魏艳玲,范丽玲,肖潇,颜綦先,李娅,陈东风..非酒精性脂肪性肝病与心血管疾病的相关性分析[J].实用肝脏病杂志,2013,(6):499-501,3.基金项目
国家自然科学基金青年科学基金项目（81200297）；国家自然科学基金项目 （）
