实用肝脏病杂志Issue(6)：517-519,3.DOI:10.3969/j.issn.1672-5069.2013.06.013
干扰素α-2b联合利巴韦林治疗慢性丙型肝炎患者疗效观察
A clinical observation of interferon alfa-2b plus ribavirin in treatment of patients with chronic hepati-tis C
田慧 1和振坤 1徐庆杰1
作者信息
- 1. 475000河南省开封市 河南大学淮河医院感染内科
- 折叠
摘要
Abstract
Objective To observe the clinical efficacy of interferon alfa-2b and ribavirin in the treatment of patients with chronic hepatitis C. Methods 87 patients with chronic hepatitis C were randomly divided into two groups,and the patients in both groups were treated with interferon alfa-2b and ribavirin. The regimen lasted for 48 weeks in 44 patients in control and for 72 weeks in 43 patients in the observation group. All the patients were followed-up for 24 weeks after discontinuation of the treatment. Results The HCV genotype 1b and 2a infections were found in 28(63.6%)and 8 patients(18.2%)in the control group,while they were in 29(67.4%)and 6 patients(14.0%)in the observation groups;The rapid virologic response(RVR),early virologic response(EVR), virologic response at the end of treatment(ETR)and sustained virologic response(SVR)in control group were 40.9%, 59.1%,68.2% and 38.6%,respectively,while they were 39.5%,60.5%,88.4%(P<0.05)and 65.1%(P<0.05),respec-tively in the observation group;We divided the patients in both groups into with high and low serum virologic loads as their serum HCV RNA≥1í106copies/m1,the ETR and SVR in patients with low serum virologic load in both groups were higher than those in patients with high serum viral loads (P<0.05). Conclusion Prolonged course of interferon-α and ribavirin treatment in patients with chronic hepatitis C might improve the efficacy and get higher SVR.关键词
慢性丙型肝炎/普通干扰素/利巴韦林/治疗Key words
Chronic hepatitis C/Interferon alfa-2b/Vibavirin/Sustained virologic response引用本文复制引用
田慧,和振坤,徐庆杰..干扰素α-2b联合利巴韦林治疗慢性丙型肝炎患者疗效观察[J].实用肝脏病杂志,2013,(6):517-519,3.
