实用肝脏病杂志Issue(1)：71-73,3.DOI:10.3969/j.issn.1672-5069.2014.01.021
原发性肝癌患者微波消融治疗后外周血T淋巴细胞亚群的变化
Changes in peripheral T lymphocyte subsets in patients underwent microwave ablation for primary liver cancer
阚晓 1潘家超 2荆燕 3都晓伟 4史兆章 1韩绍磊 1张海涛 1郑昭敏1
作者信息
- 1. 250021 济南市 山东大学附属济南市传染病医院介入科
- 2. 250021 济南市 山东大学附属济南市传染病医院医学院
- 3. 250021 济南市 山东大学附属济南市传染病医院检验室
- 4. 山东省潍坊市昌乐县人民医院感染病科
- 折叠
摘要
Abstract
Objective To investigate the changes of peripheral T lymphocyte subsets in patients with prima-ry liver cancer (PLC)underwent microwave ablation. Method 152 patients with PLC were recruited and received microwave ablation treatment. One day before,and 1 week and 4 weeks after the treatment,the distributions of peripheral T lymphocyte subsets were determined by flow cytometry,and serum levels of alpha fetoprotein were measured by a automatic biochemical immune analyzer. Contrast-enhanced CT scans were performed in all pa-tients one month after the treatment. Results The percentages of CD4+ or CD8+T lymphocytes and the ratio of CD4+/CD8+in this series one day before the treatment were (21.4±4.1)%,(58.6±7.8)% and(0.98±0.45),respective-ly,while the percentages of CD4+T lymphocytes increased to (26.5±3.8)% and(32.3±5.1)%,and the CD4+/CD8+ra-tio increased to(1.12 ±0.43)and(1.51 ±0.40),but CD8+T lymphocytes decreased to(47.2 ±7.7)% and (28.1 ±7.3)%, respectively (P<0.05)one week and 4 weeks after microwave ablation; serum alpha fetoprotein levels were signifi-cantly decreased from the baseline [(1109±727) ng/ml] to (890±681) ng/ml 1 week or (215±18) ng/ml 4 weeks after ablation (P<0.01);contrast-enhanced CT scans revealed a complete ablation rate of 97.37%(148/152) for tumors one month after therapy. Conclusions Microwave ablation for PLC shifts the distribution of peripheral blood T lym-phocyte subsets toward a CD4+ cells-favorite status,which might play a role in improving the efficacy of the therapy.关键词
原发性肝癌/淋巴细胞亚群/微波消融/CD4+/CD8+Key words
Hepatoma/Microwave ablation/T lymphocyte subsets引用本文复制引用
阚晓,潘家超,荆燕,都晓伟,史兆章,韩绍磊,张海涛,郑昭敏..原发性肝癌患者微波消融治疗后外周血T淋巴细胞亚群的变化[J].实用肝脏病杂志,2014,(1):71-73,3.
