实用肝脏病杂志Issue(1)：74-77,4.DOI:10.3969/j.issn.1672-5069.2014.01.022
肝移植术后丙型肝炎复发受者肝组织病理学特征分析
Liver histopathological characteristics of recurrent hepatitis C in patients with liver transplantation
摘要
Abstract
Objective To explore the liver histopathological characteristics of recurrent hepatitis C in pa-tients with liver transplantation. Methods 54 liver biopsies were obtained from 28 patients who were diagnosed as recurrent hepatitis C after liver transplantation. Results The main liver pathological features of recurrent hep-atitis C in patients with liver transplantation included liver cell degeneration and necrosis ,lymphocyte and other inflammatory cell aggregation in the portal area,and early occurrence of fibrosis;Besides,liver histopathological features of rejection reaction and drug-induced liver injury were also present in some cases;Liver fibrosis of re-current hepatitis C in late periods (>12 months) after liver transplantation was significant severe than in patients with recurrent hepatitis C at early periods(the liver staging score were (1.82±1.12) and (1.13±1.08),respectively, P<0.05);No significant differences in pathological manifestations among different viral genotypes of HCV infection were found;Histological activity index in patients with rejection reaction and drug-induced liver injuries were(2.32± 0.64)and (2.33±0.88),respectively,much higher than that in cases without rejection reaction or drug-induced liver injuries (1.64 ±0.59),(P<0.05). Conclusion Hepatitis C recurrence after liver transplantation has characteristic changes in liver pathology,and liver pathological examination in time might help evaluating the liver injuries of hepatitis C recurrence after liver transplantation.关键词
肝移植/丙型肝炎/复发/病理学Key words
Liver transplantation/Hepatitis C/Recurrence/Liver pathology引用本文复制引用
周双男,陈金旭,张敏,苏海滨,张宁,孙艳玲,刘振文,向轶,高银杰,周霞,张达利..肝移植术后丙型肝炎复发受者肝组织病理学特征分析[J].实用肝脏病杂志,2014,(1):74-77,4.基金项目
2011年解放军第302医院院长创新基金资助项目 （）
