实用肝脏病杂志Issue(1)：109-112,4.DOI:10.3969/j.issn.1672-5069.2014.01.035
原发性胆汁性肝硬化发病相关危险因素研究进展
Risk factors for the pathogenesis and progression of primary biliary cirrhosis
摘要
Abstract
Primary biliary cirrhosis(PBC) is considered as an idiopathic autoimmune liver disease,mainly found in mid-dle-aged women. Out of many related risk factors,the demographic factors,environmental factors and genetic factors as well as family history,smoking history and urinary tract infections,have always been thought to be important. In recent years,with the progress in basic and clinical research,especially the application of genome-wide association study technology,scholars found some genes,such as human leukocyte antigen genes,interleukin (IL)-12 and the X chromosome monomer,etc,may lead to this disease. In the future,more samples and GWAS data are needed to verify those new findings to elaborate the pathogenesis of the disease in genetic level.关键词
原发性胆汁性肝硬化/危险因素/环境因素/遗传易感性Key words
Primary biliary cirrhosis/Risk factors/Environmental factors/Hereditary susceptibility引用本文复制引用
李远军(综述),韩者艺,韩英(审校)..原发性胆汁性肝硬化发病相关危险因素研究进展[J].实用肝脏病杂志,2014,(1):109-112,4.基金项目
国家自然科学基金资助项目 （）
