实用肝脏病杂志Issue(2)：154-158,5.DOI:10.3969/j.issn.1672-5069.2014.02.011
2002至2011年中国“北方”地区住院肝硬化患者病因构成及变化趋势分析
Etiologic changes in patients with liver cirrhosis from 2002 to 2011 in North China
摘要
Abstract
Objective To analyze the changes in cirrhotic etiologies of inpatients from 2002 to 2011 in North China. Methods Cirrhotic etiologies and its changes were analyzed in 53092 patients with liver cirrhosis for the first time in our hospital from 2002 to 2011. Results Hepatitis B related cirrhosis (74.2%),hepatitis C related cirrhosis (10.8%),alcoholic cirrhosis (5.8%) and auto-immune liver diseases related cirrhosis (3.9%) were the top four etiologies;The percentage of hepatitis B related cirrhosis was decreased from 81.5% in 2002 to 66.8% in 2011,while the percentage of alcoholic cirrhosis was increased from 3.3% to 7.7%,a 2.3-time increase in 10 years;Patients with auto-immune liver diseases related cirrhosis were mainly female (84.3%) and patients with hepatitis B related cirrhosis and alcoholic cirrhosis were mainly male(80.0% and 98.0%,respectively,P<0.01);The average age was less than 50 years in patients with alcoholic cirrhosis and hepatitis B related cirrhosis, while the average age was greater than 50 years old in patients with hepatitis C related cirrhosis and auto-im-mune liver diseases related cirrhosis (P<0.01);For all patients,North China ranked first in patient’s family regis-ter,but for patients with alcoholic cirrhosis and auto-immune liver diseases related cirrhosis,Beijing and East Chi-na ranked the second and third place,respectively,in patient’s family register;The top three places accounted for 79.7% of patients with alcoholic cirrhosis;The improvement rate were greater than 70% in patients with the top four etiologies related cirrhosis,and the improvement rate were even higher (80%) in patients with alcoholic cir-rhosis and auto-immune liver diseases related cirrhosis (P<0.01). Conclusions Hepatitis B,hepatitis C,alcohol and auto-immune liver diseases are the top four etiologies of liver cirrhosis. The percentage of hepatitis B related cirrhosis is gradually decreasing,while the percentage of alcoholic cirrhosis is increasing from 2002 to 2011 in North China.关键词
肝硬化/病因/临床特点/流行趋势Key words
Liver cirrhosis/Etiology/Clinical features/Epidemic changes引用本文复制引用
王晓霞,邹正升,李保森,管群,孙颖,常彬霞,滕光菊,李进..2002至2011年中国“北方”地区住院肝硬化患者病因构成及变化趋势分析[J].实用肝脏病杂志,2014,(2):154-158,5.基金项目
国家自然科学基金资助项目 （）
