实用肝脏病杂志Issue(3)：245-248,4.DOI:10.3969/j.issn.1672-5069.2014.03.007
慢性乙型肝炎患者肝组织基质金属蛋白酶组织抑制物-1表达及其意义
Clinical significance of tissue inhibitor of metalloproteinases-1 in livers of patients with chronic hepatitis B
摘要
Abstract
Objective To evaluate the expression of tissue inhibitor of metalloproteinases-1 (TIMP-1) in livers of patients with chronic hepatitis B (CHB) and to explore the potential relationship between TIMP-1 level and hepatic fibrosis progression. Methods The tissue and serum levels of TIMP-1 were determined by immuno-histochemistry and double-antibody sandwich enzyme-linked immunoadsorbent assay,respectively,and their correla-tion was determined. One hundred and fifty-nine patients with CHB underwent liver biopsy and their liver histo-logical activity index (HAI) and fibrosis (S) were determined. The correlation between the serum TIMP-1 levels and HAI grading and staging was analyzed. Results The expression of TIMP-1 in liver tissues were positively correlated to serum TIMP-1 levels in CHB patients(r=0.9521,P<0.01);Serum TIMP-1 levels were significant dif-ferent among patients with different liver fibrosis stages (S1 to S4)(P<0.05),and a positive correlation between serum TIMP-1 level and hepatic fibrosis staging was found (r=0.704,P<0.01);However,there were no significant differences in serum TIMP-1 levels among patients with different liver inflammatory grades. Conclusions Serum TIMP-1 level is not affected by liver inflammatory grades and is promising in non-invasive clinical evaluation of liver fibrosis.关键词
慢性乙型肝炎/基质金属蛋白酶组织抑制物 -1/肝纤维化/炎症Key words
Chronic hepatitis B/Tissue inhibitor of metalloproteinases-1/Hepatic fibrosis/Inflammation引用本文复制引用
朱传龙,李毓雯,李文庭,李宜,高人焘..慢性乙型肝炎患者肝组织基质金属蛋白酶组织抑制物-1表达及其意义[J].实用肝脏病杂志,2014,(3):245-248,4.基金项目
国家自然科学基金资助项目（81271713）；安徽省第五批优秀青年科技基金滚动支持项目（1308085JGD09）；安徽医科大学校长基金资助项目 （）
