实用医学杂志Issue(4)：545-547,3.DOI:10.3969/j.issn.1006-5725.2014.04.014
miR-96-5p在肝细胞癌根治术后早期复发患者中的表达及其临床意义
Expression and clinical significance of miR-96-5p in primary hepatocellular carcinoma at early recurrence after radical surgery
摘要
Abstract
Objective To investigate the expression and clinical significance of miR-96-5p in primary hepatocellular carcinoma (HCC) at early recurrence after radical surgery. Methods 61 HCC eryopreservation tissue samples from the liver carcinoma specimens data obtained after radical surgery and banked in our hospital were divided into 2 groups: early recurrence group (33 cases) and non-early recurrence group (28 cases). Aquantitative real-time polymerase chain reaction (qRT-PCR) was performed to detect the expression of miR-96-5p. Results Compared with the non-early recurrence group , the expression of miR-96-5p was observably down-regulated [(0.634 ± 0.783) vs (5.182 ± 11.321), P = 0.043]. The expression of miR-96-5p was correlated to tumor diameter, early recurrence and vascular invasion (P<0.05). Conclusions miR-96-5p are significantly related to early liver cancer recurrence and metastasis. miR-96-5p may be a molecular marker of HCC at early recurrence as well as a target for targeted therapy of liver cancer in future.关键词
原发性肝细胞癌/miR-96-5p/早期复发/实时荧光定量PCRKey words
Primary hepatocellular carcinoma/miR-96-5p/Early recurrence/Quantitative real-time PCR引用本文复制引用
赖清波,金浩生,简志祥..miR-96-5p在肝细胞癌根治术后早期复发患者中的表达及其临床意义[J].实用医学杂志,2014,(4):545-547,3.基金项目
广东省自然科学基金 （）
