实用医学杂志Issue(4)：548-551,4.DOI:10.3969/j.issn.1006-5725.2014.04.015
透明质酸钠与塞来昔布治疗膝骨关节炎的临床随机对照研究
Randomized,controlled clinical trial comparison of sodium hyaluronate versus celecoxib in knee osteoarthritis patients
摘要
Abstract
Objective To compare the effects of sodium hyaluronate (SH) and celecoxib (CO) administration on the treatment of knee osteoarthritis (OA) and to investigate their influences on levels of uPA and MMP-3 in synovial fluid. Methods One hundred and thirty-six knee osteoarthritis (OA) patients from January 2010 to October 2011 were randomly enrolled into two groups: the SH group and the CO group. In the SH group, patients were injected with 2 mL sodium hyaluronate intra articulation once a week for 5 weeks. In the CO group , patients were given oral administration of celecoxib daily at a dosage of 200 mg for 5 weeks. Before and at 1 ,6 months after treatment, Lequesne′s index and VAS-pain were detected to assess the clinical results of these two drugs. The levels of uPA and MMP-3 in synovial fluid were measured by using ELISA assay. Results All patients were followed up for 6 months to 12 months. The Lequesne′s index and VAS-pain score were lowered at 1 and 6 moths after treatment in both the SH group and the CO group(P<0.05). In the CO group, however, higher Lequesne′s index and VAS-pain score were obtained at 6 months compare to that obtained at 1 month after treatment (P<0.05). In contrast, no significant difference of Lequesne′s index and VAS-pain score were shown at 6 months and at 1 month after treatment in the SH group (P>0.05). Dramatic reduction of the levels of uPA and MMP-3 in synovial fluid were observed in the SH group after treatment(P<0.01), while marginal changes were found in the CO group(P>0.05). Conclusion The redueced levels of uPA and MMP-3 in synovial fluid after treatment of sodium hyaluronate may contribute to its longer-lasting effect than that of celecoxib. Therefore , the combination of sodium hyaluronate with celecoxib may lead to better therapeutic effect on OA patients.关键词
骨关节炎/透明质酸钠/塞来昔布/关节液/疗效Key words
Osteoarthritis/Sodium hyaluronate/Celecoxib/Synovial fluid/Clinical effects引用本文复制引用
王维山,史晨辉,李长俊,张振东,陈安民,郭风劲..透明质酸钠与塞来昔布治疗膝骨关节炎的临床随机对照研究[J].实用医学杂志,2014,(4):548-551,4.基金项目
国家自然基金资助课题 （）
