实用医学杂志Issue(4)：551-553,3.DOI:10.3969/j.issn.1006-5725.2014.04.016
多囊卵巢综合征不孕患者血清Apelin水平与胰岛素抵抗的关系
Relation between serum Apelin level and insulin resistance in infertility patients with polycystic ovarian syndrome
摘要
Abstract
Objective To explore the change of serum Apelin level and its relationship with insulin resistance (IR) in infertility patients with polycystic ovarian syndrome (PCOS). Methods Ninety-eight infertility patients with PCOS (PCOS group) and 72 infertility patients without PCOS (non-PCOS group) visiting our hospital for the first time from January 2011 to June 2012 were selected. The BMI , serum Apelin level (detected by ELISA), fasting blood glucose (FPG, detected by glucose oxidase method), fasting insulin (Fins, detected by chemiluminescence), and homeostasis model assessment of insulin resistance index (HOMA-IR) of the two groups were detected. Results The serum Apelin level and HOMA-IR in PCOS patients were higher than those in non-PCOS patients (3.28 ± 1.24 vs. 1.94 ± 0.78, P < 0.05; 3.84 ± 1.23 vs. 2.14 ± 0.77,P < 0.05). Pearson correlation analysis showed that serum Apelin level was positively correlated with HOMA-IR in PCOS patients (r=0.65, P<0.01). Conclusions The serum Apelin level in infertility patients with PCOS increased evidently, and was positively correlated with HOMA-IR; which indicated that Apelin may involve in the development of IR in infertility patients with PCOS.关键词
多囊卵巢综合征/胰岛素抵抗/不孕/ApelinKey words
Polycystic ovary syndrome/Insulin resistance/Infertility/Apelin引用本文复制引用
黄红艺,莫云,何冰,刘杨桦,张团英,张凤兰..多囊卵巢综合征不孕患者血清Apelin水平与胰岛素抵抗的关系[J].实用医学杂志,2014,(4):551-553,3.基金项目
2013年广西壮族自治区卫生厅自筹经费课题项目 （）
