实用医学杂志Issue(4)：560-562,3.DOI:10.3969/j.issn.1006-5725.2014.04.019
Nanog和CD44蛋白在肺癌中的表达及其临床意义
Expressions and clinical significance of Nanog and CD44 protein in lung cancer
摘要
Abstract
Objective To detect the expressions and clinical significance of Nanog and CD44 protein in lung cancer. Methods The expressions of Nanog and CD44 were detected by immunohistochemistry in 50 cases of lung cancer, 32 cases of benign lesion lung tissue and 18 cases of paraneoplastic normal lung tissue. Then their relationships with clinicopathological factors were analyzed. Results The expression of Nanog in lung cancer was significantly higher than those in benign lesion lung tissue and paraneoplastic normal lung tissue (P < 0.05). There was no significant difference of the expression of CD44 among the three groups (P > 0.05). The expressions of Nanog and CD44 in squamous cell carcinomas were higher than those in adenocarcinomas and small cell lung carcinomas (P < 0.05). The expressions of Nanog and CD44 were significantly correlated with lymph node metastasis (P < 0.05), but were not correlated with age, gender, tumour size, TNM stage and differentiation of lung cancer (P>0.05). The positive correlation was also noted between the expressions of Nanog and CD44 in lung cancer (r = 0.564, P < 0.05). Conclusion Nanog and CD44 proteins may participate in the genesis and progression of lung cancer. Nanog protein is a potential diagnostic marker and therapeutic target for lung cancer.关键词
肺肿瘤/Nanog/CD44/诊断标志物/治疗靶点Key words
Lung neoplasms/Nanog/CD44/Diagnostic marker/Therapeutic target引用本文复制引用
莫碧文,李劳冬,王昌明,曾锦荣,王绩英,韦江红,陈峰,黄剑伟,于会娜..Nanog和CD44蛋白在肺癌中的表达及其临床意义[J].实用医学杂志,2014,(4):560-562,3.基金项目
广西卫生厅重点科研项目 （）
