实用医学杂志Issue(5)：758-760,3.DOI:10.3969/j.issn.1006-5725.2014.05.026
5-羟色胺1A受体C（-1019）G基因多态性与老年抑郁症和伴有抑郁症状的阿尔茨海默病的关联研究
Association between the 5-HT1A receptor gene C (-1019)G polymorphism and geriatric depression and Alzheimer′s disease with depressive symptoms
摘要
Abstract
Objective To investigate the relationship between the 5-hydroxytryptamine (5-HT)1A receptor gene C(-1019)G polymorphism and geriatric depression and Alzheimer′s disease (AD) with depressive symptoms in Han Chinese. Methods The case control study was used in the study among 106 patients with geriatric depression, 72 AD patients with depressive symptoms and 150 healthy old individuals in China. The C(-1019)G polymorphism of 5-HT1A was analyzed with the technique of polymerase chain reaction-restriction fragment length polymorphism. Results The frequencies of 5-HT1A genotype C/G (39.6%), G/G(24.5%) and allele G (44.3%) in the patients with geriatric depression were significantly higher than those in the controls (respectively 35.3%, 13.3%, 31.0%, P < 0.05). The frequencies of 5-HT1A G allele in the AD patients with depressive symptoms (41.0%) were significantly higher than those in the controls (31.0%,X2=4.2879, P<0.05). No significant difference in distribution of (5-HT)1A C (-1019) G polymorphism between the patients with geriatric depression and the AD patients with depressive symptoms was observed (P > 0.05). Conclusion The 5-HT1A gene C (-1019)G polymorphism may be associated with geriatric depression and AD with depressive symptoms and (-1019)G allele may be a risk factor for them.关键词
抑郁症/阿尔茨海默病/老年/5-羟色胺1A受体/基因多态性Key words
Depressive disorder/Alzheimer disease/Aged/5-HT1A/Gene polymorphism引用本文复制引用
饶冬萍,陈建华,温全球,黄杏笑,沐楠,陈建平,徐世超,韩海英,刘文滔..5-羟色胺1A受体C（-1019）G基因多态性与老年抑郁症和伴有抑郁症状的阿尔茨海默病的关联研究[J].实用医学杂志,2014,(5):758-760,3.基金项目
广东省医学科研基金项目（编号B2011275）；广州市医药卫生科技项目 （）
