实用医学杂志Issue(5)：812-815,4.DOI:10.3969/j.issn.1006-5725.2014.05.045
磺达肝癸钠与依诺肝素在中国人急性冠脉综合征PCI术后疗效及安全性的前瞻性研究
Prospective study on efficiency and safety of fondaparinux and enoxaparin in treatment of Chinese patients with acute coronary syndrome having undergoneing PCI
简冬冬 1高传玉 2李牧蔚2
作者信息
- 1. 450000 郑州大学第一附属医院
- 2. 450000 郑州市，河南省人民医院
- 折叠
摘要
Abstract
Objective To study efficiency and safety of fondaparinux and Enoxaparin in treatment of Chinese patients with acute coronary syndrome (ACS) having undergone percutaneous coronary intervention (PCI). Methods One thousand and sixty ACS patients (945 with unstable angina, 115 with AMI) having undergone PCI in Henan provincial hospital from July 2011 to July 2013 were randomized into two groups treated with fondaparinux or enoxaparin respectively. Apart from treatment with oral aspirin and clopidogrel, those in the former group were treated with fondaparinux (2.5 mg IH QD) and the latter with enoxaparin (60 mg IH Q12H) subcutaneously for 2 days before operation, both suspended for 12 h before the operation. All of the patients were given heparin (60 IU/kg) during the operation. After the operation, the therapies with fondaparinux (2.5 mg IH QD) and enoxaparin (60 mg IH Q12H) were resumed subcutaneously for 3 days. Perioperative observation and follow-ups were made in terms of hemorrhage, thrombosis and major adverse cardiac events (MACE) in the patients during the hospitalization period, 2 and 4 weeks after operation. Results Fondaparinux and enoxaparin are both effective on anticoagulation for the patients after PCI. There was no significant difference about the incidence of MACE between the two groups (P > 0.05). But, fondaparinux group had lower incidence of hemorrhage than enoxaparin group (P < 0.05). Conclusion Fondaparinux and enoxaparin both have good anticoagulant activity in Chinese patients with ACS undergoing PCI, but fondaparinux may lower the risk of hemorrhage compared to enoxaparin.关键词
冠状动脉疾病/磺达肝癸钠/依诺肝素/急性冠脉综合征/PCI术Key words
Coronary artery disease/Fondaparinux/Enoxaparin/ACS/PCI引用本文复制引用
简冬冬,高传玉,李牧蔚..磺达肝癸钠与依诺肝素在中国人急性冠脉综合征PCI术后疗效及安全性的前瞻性研究[J].实用医学杂志,2014,(5):812-815,4.
