特产研究Issue(1)：44-48,5.
硫酸香茅醛显色法测定莪术油微囊载药量与包封率
Determination of Drug Loading Capacity and Encapsulation Efficiency in Zedoary Turmericoil Microcapsules by Sulfuric Acid - vanillin Coloration Method
吴继龙 1张立华 2陈欢 1杨丽娜 1代英辉 1王东 3刘东春1
作者信息
- 1. 沈阳药科大学中药学院，沈阳 110016
- 2. 大连华立金港药业有限公司，辽宁 大连 116100
- 3. 沈阳药科大学中韩分子生药学研究室，沈阳 110016
- 折叠
摘要
Abstract
In order to evaluate the quality of Zedoary turmeric oil/(maltodextrin-Povacoat) microcapsules(ZTO/M-P Mcs) ,a sulfuric acid-vanillin coloration method for determination of drug loading capacity and encapsulation efficiency was developed .Wavelength scanned on the ZTO ethanol solution was determined at 508nm as the maximum absorption wavelength .Color stability tests showed that the absorbance of reac-tion solutions was stabled at 150 minutes .Absorbance and concentration of ZTO had a good linear relationship in the range of 0.199 2μg/mL~9.96μg/mL (A=0.094 7C-0.001 2 ,r=0.999 3 ) ,the average recovery of determination of drug loading capacity and encapsulation efficien-cy were 99.6% and 99.1% respectively .According to assay results of 3 batches ,drug loading was 51.5mg/g~53.2mg/g;Encapsulation effi-ciency was 88.2% ~90.7% .关键词
莪术油/聚乙烯酸·丙烯酸·甲基丙烯酸甲酯共聚物/微囊/载药量/包封率/硫酸香茅醛显色法Key words
zedoary turmeric oil/povacoat/microcapsules/drug loading capacity/encapsulation efficiency/sulfuric acid -vanillin coloration method分类
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吴继龙,张立华,陈欢,杨丽娜,代英辉,王东,刘东春..硫酸香茅醛显色法测定莪术油微囊载药量与包封率[J].特产研究,2014,(1):44-48,5.
