西安交通大学学报（医学版）Issue(3)：390-393,4.DOI:10.7652/jdyxb201403023
CD147和MMP-9在喉鳞癌中的表达及意义
Expressions of CD147 and MMP-9 in laryngeal squamous cell carcinoma and their significance
王德生 1蒋远伟 1黄建民 1林树春 1赖海春1
作者信息
- 1. 福建医科大学附属协和医院耳鼻咽喉科，福建福州 350001
- 折叠
摘要
Abstract
Objective To investigate the expressions of CD147 and matrix metalloproteinases-9 (MMP-9)in laryngeal squamous cell carcinoma (LSCC)tissue and their clinical significance.Methods The expressions of CD147 and MMP-9 were analyzed semi-quantitatively by immunohistochemical staining in LSCC and control group tissues.Results ① The positive rate of CD147 was 83.3% (30/36)in LSCC,which was higher than that in laryngeal polyp (33.3%,5/15)and in adjacent normal tissue (16.7%,6/36);it was related to histological grade, clinical stage and lymph node metastasis status (P<0 .0 5 ).② The positive rate of MMP-9 was 7 2 .2% (2 6/3 6 )in LSCC,which was higher than that in laryngeal polyp (13.3%,2/15)and in adjacent normal tissue (5.6%,2/36);it was related to histological grade,T stage,clinical stage and lymph node metastasis status (P<0.05).③ There was a positive correlation between the expressions of CD147 and MMP-9 in LSCC tissue (r=0.721,P=0.000). Conclusion The over-expressions of CD147 and MMP-9 in LSCC may contribute to the development and metastasis of LSCC.关键词
鳞状细胞癌/喉肿瘤/细胞外基质金属蛋白酶诱导因子(EMMPRIN/CD147)/基质金属蛋白酶-9(MMP-9)Key words
squamous cell carcinoma/laryngeal neoplasm/extracellular matrix metalloproteinase inducer (EMMPRIN)/matrix metalloproteinases-9 (MMP-9)分类
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王德生,蒋远伟,黄建民,林树春,赖海春..CD147和MMP-9在喉鳞癌中的表达及意义[J].西安交通大学学报（医学版）,2014,(3):390-393,4.
