陕西科技大学学报（自然科学版）Issue(6)：132-135,4.
奥硝唑β-环糊精包合物的制备
Preparation of ornidazole β-cyclodextrin inclusion complexes
摘要
Abstract
Ornidazole β-cyclodextrin inclusion complexes were prepared by saturated water so-lution ,and their structures were characterized by microscope and IR .The solubility and sta-bility of ornidazole β-cyclodextrin inclusion complexes were evaluated .The preparation condi-tion were selected by L9 (34 ) orthogonal experimental design .Results have shown that ornidazole and β-cyclodextrin can form inclusion complex ,and the aqueous solubility and sta-bility were increased when ornidazole was included by β-cyclodextrin .The optimum prepara-tion conditions of ornidazole β-cyclodextrin inclusion complexes were established as follows :the quality ratio of ornidazole and β-cyclodextrin was 1∶1 ,reaction time for was 3 h ,inclu-sion temperature was 60 ℃ ,and yield was 73 .10% ,the inclusion rate of the complex was 24 .53% .关键词
奥硝唑/β-环糊精/包合物/制备工艺Key words
ornidazole/β-cyclodextrin/inclusion/preparation conditions分类
医药卫生引用本文复制引用
常相娜,沈文,周璐璐,张莉..奥硝唑β-环糊精包合物的制备[J].陕西科技大学学报（自然科学版）,2013,(6):132-135,4.基金项目
陕西省教育厅专项科研计划项目（2013JK0767）；陕西省科技厅自然科学基础研究计划项目（2011JM2005）；陕西科技大学自然科学基金项目 （）
