中国组织工程研究Issue(40)：7132-7137,6.DOI:10.3969/j.issn.2095-4344.2013.40.017
干细胞治疗阿尔茨海默病的现状及未来
Stem cells for the treatment of Alzheimer’s disease
摘要
Abstract
BACKGROUND:Scientists began to use stem cells to treat Alzheimer’s disease since human beings achieved embryonic stem cells successful y in 1998. <br> OBJECTIVE:To review the research progress in stem cells treatment for Alzheimer’s disease. <br> METHODS:An online search of CNKI and PubMed databases was performed for articles published from 1998 to 2012 (CNKI) using key words of“Alzheimer’s disease, stem cells, neural stem cells, mesenchymal stem cells, induced pluripotent stem cells”in Chinese and English, respectively. The articles were included which related to Alzheimer’s disease, neural stem cells, mesenchymal stem cells and induced pluripotent stem cells, and for articles in the same field, those published recently or in authorized journals were selected. A total of 85 articles were searched. According to inclusion and exclusion criteria, 29 were included. <br> RESULTS AND CONCLUSION:The possible mechanisms of Alzheimer’s disease include differentiation of neural-like cells, secretion of nutrition factor, improvement of endogenous repair, stimulation of vascular regeneration and action on inflammatory cells. This review highlighted research status of neural stem cells, mesenchymal stem cells and induced pluripotent stem cells in the treatment of Alzheimer’s disease. There were advantages and disadvantages for al of them. The low immunogenicity and oncogenicity of neural stem cells are advantages, but limited source reduces their application. Mesenchymal stem cells also have low immunogenicity and oncogenicity, but their differentiation potential is not good as embryonic stem cells. Induced pluripotent stem cells also have many unsolved problems, but they have been regarded as promising stem cells.关键词
干细胞/干细胞综述/阿尔茨海默病/神经干细胞/间充质干细胞/诱导多能干细胞/嗅鞘细胞/脑源性神经营养因子/人脐带间充质干细胞/人羊膜间充质干细胞/脂肪间充质干细胞/省级基金分类
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刘晓峰,吴迪,吴岩..干细胞治疗阿尔茨海默病的现状及未来[J].中国组织工程研究,2013,(40):7132-7137,6.基金项目
干细胞专项基金，内蒙古财政厅([2005]1162)；内蒙古自治区科技厅，干细胞应用技术创新团队基金(kjt09)@@@@the Specific Funds for Stem Cel s, Department of Finance, Inner Mongolia Autonomous Region, No.[2005]1162 （[2005]1162）
Stem Cel Application Technique Innovation Group Foundation, Department of Science and Technology, Inner Mongolia Autonomous Region, No. kjt09 （）
