中国组织工程研究Issue(41)：7284-7289,6.DOI:10.3969/j.issn.2095-4344.2013.41.015
特应性皮炎模型小鼠的生长繁殖及血液生理生化指标
Growth, reproduction and blood physiological and biochemical indexes in an atopic dermatitis mouse model
摘要
Abstract
BACKGROUND:The skin lesions, pathological and immunological characteristics of Nc/Nga mice are consistent with human atopic dermatitis, and as an atopic dermatitis animal model, it has great research value. But there are no reports on the physiological and biochemical parameters of Nc/Nga mice in China. OBJECTIVE:To observe the growth and reproduction and blood physiological and biochemical parameters of atopic dermatitis model of NC/Nga mice METHODS:The data of reproductive performance of NC/Nga mice from the first to the third generation was analyzed, including mean litter size, weaning rate, pregnancy rate and generation interval. The body mass of 60 Nc/Nga mice with 1-56 days old was measured, 30 mice of female and male, then the growth curve was draw. The blood samples from the infraorbital vessels were col ected to detect the blood physiological and biochemical parameters in the mice. RESULTS AND CONCLUSION:The mean delivery interval of Nc/Nga mice was (25.8±3.1) days, mean litter size was (7.5±2.5) mice, mean weaning rate was (97.2±1.2)%, the mean pregnancy rate was (97.0±1.4)%, and there was no significant difference among the three generations of these mice (P>0.05). The body mass of Nc/Nga mice was increased with the time increasing of days, the body mass of the mice was maximal within 1-2 weeks post-weaning, and there was no significant difference in body mass between males and females at 6 weeks post-weaning (P>0.05). Comparison of the blood physiological and biochemical parameters of mice at the same age between males and females showed that the levels of red blood cells and hemoglobin in female mice were significantly higher than those in the male mice;the platelet count in the male mice was significantly higher than that in the female mice (P<0.05);the triglycerides and albumin levels in the female mice were higher than those in the male mice (P<0.05). The results indicate that the gender and age may influence the blood physiological and biochemical parameters of Nc/Nga mice.关键词
组织构建/组织构建实验造模/Nc/Nga鼠/特应性皮炎/生长率/血液生理生化指标/分娩间隔/产仔数/离乳率/省级基金Key words
skin diseases/models/animal/growth/breading/blood chemical analysis分类
医药卫生引用本文复制引用
童敏,梁云生,张桂英..特应性皮炎模型小鼠的生长繁殖及血液生理生化指标[J].中国组织工程研究,2013,(41):7284-7289,6.基金项目
湖南省科研条件创新专项计划资助项目(2011TT2019) （2011TT2019）
