中国组织工程研究Issue(42)：7469-7474,6.DOI:10.3969/j.issn.2095-4344.2013.42.020
氟尿嘧啶缓释剂在进展期胃癌治疗中的应用
Fluorouracil sustained release agent in the treatment of advanced gastric cancer
张斌 1王兵济 1李增才 1刘现忠 1王轩1
作者信息
- 1. 解放军第八一医院肿瘤外科，江苏省南京市 210002
- 折叠
摘要
Abstract
BACKGROUND:Fluorouracil sustained-release agent is a commonly used anti-cancer sustained-release drug, which has a good anti-tumor effect. <br> OBJECTIVE:To explore the effect of fluorouracil sustained-release agent in the treatment of gastric cancer. METHODS:Literatures concerning the effect of fluorouracil sustained-release agent in the treatment of gastric cancer were retrieved and analyzed. In the paper, we investigated the preventive effect of fluorouracil sustained-release agent against tumor recurrence and metastasis after radical resection, and fol owed up the patients who underwent clinical peritoneal implantation of fluorouracil sustained-release agent. We could determine the effect of fluorouracil sustained-release agent in the treatment of advanced gastric cancer by observing the patient’s symptoms and signs, expression of tumor markers, tumor size and survival rate. <br> RESULTS AND CONCLUSION:After combination therapy of fluorouracil sustained-release agent and arterial infusion chemotherapy adjuvant therapy, the patient’s symptoms and tumor resection rate were significantly improved. The levels of CEA, CA19-9, CA72-4 in the serum of patients significantly reduced, while the apoptosis and necrosis of tumor cells significantly increased. Fluorouracil sustained-release agent could also reduce tumor metastasis and local recurrence, and improve patient survival.关键词
生物材料/生物材料学术探讨/胃癌/氟尿嘧啶/缓释/肿瘤/腹腔转移/肝转移/奥沙利铂/动脉灌注Key words
digestive system diseases/stomach diseases/neoplasms by site/digestive system neoplasms/stomach neoplasms分类
医药卫生引用本文复制引用
张斌,王兵济,李增才,刘现忠,王轩..氟尿嘧啶缓释剂在进展期胃癌治疗中的应用[J].中国组织工程研究,2013,(42):7469-7474,6.
