中国组织工程研究Issue(44)：7729-7732,4.DOI:10.3969/j.issn.2095-4344.2013.44.012
生物型异种骨软骨移植修复关节软骨缺损
Articular cartilage defect treated with biological osteochondral xenogenic graft transplantation
摘要
Abstract
BACKGROUND:The methods used to repair articular cartilage defects currently have the cons and pros. Fibrocartilages are commonly used to repair tissues, and the fibrocartilage lacks of the tissue biomechanical properties and chemical properties of normal hyaline cartilage. OBJECTIVE:To investigate the feasibility of biological osteochondral xenogenic graft transplantation to repair articular cartilage defects. METHODS:The normal goats were randomly divided into two groups. The donor pig knee joints were the experimental group. Cylindrical osteochondral with the diameter of 4.5 mm and length of 10 mm were col ected with the Smith&Nephew osteochondral transplantation device, and the patented technology was used for deantigen. The donor goat knee joint osteochondrals were the control group and preserved with cryopreservation. The lesions on femoral trochlea and weight-bearing surface of medial condyle were selected respectively for osteochondral implantation, and the animals were sacrificed at 16 and 32 weeks after operation for the general and pathological section observation. RESULTS AND CONCLUSION:General observation in the experimental showed that the lesions were covered by fibroid tissue;some cartilage of the grafts turned yel ow and there was clear boundary between the surface and the peripheral cartilages;the general and section observation under microscope showed that lesions of the control group were covered by the grafts basical y, and cracks could be seen on the edge of the transplant part. The results show that there is difference between effects of biological osteochondral xenogenic graft transplantation and osteochondral al ograft transplantation for the repairing of articular cartilage defects, and osteochondral al ograft transplantation bas better effect.关键词
器官移植/组织移植/异种异体/同种异体/骨软骨移植/软骨损伤/修复/羊/猪/去抗原处理/省级基金Key words
bone transplantation/cartilage, articular/transplantation, heterologous/goats/swine分类
医药卫生引用本文复制引用
沈洪园,黄华扬,张余,郑小飞,李凭跃,徐国风,王泽锦,王庆..生物型异种骨软骨移植修复关节软骨缺损[J].中国组织工程研究,2013,(44):7729-7732,4.基金项目
广东省科技计划项目(2007B031000003)@@@@Science and Technology Planning Project of Guangdong Province, No.2007B031000003 （2007B031000003）
