中国组织工程研究Issue(47)：8189-8195,7.DOI:10.3969/j.issn.2095-4344.2013.47.008
可降解金属Mg-Nd-Zn-Zr镁合金的降解行为
In vitro and in vivo degradation of Mg-Nd-Zn-Zr alloy
王勇平 1蒋垚 2毛琳 3牛佳林 4袁广银4
作者信息
- 1. 兰州大学第一医院骨科，甘肃省兰州市 730000
- 2. 上海交通大学附属第六人民医院骨科，上海市 200233
- 3. 上海交通大学附属第六人民医院骨科，上海市 200233
- 4. 上海交通大学轻合金精密成型国家工程研究中心，上海市 200240
- 折叠
摘要
Abstract
BACKGROUND:Al oying is a convenient and effective method to alter the microstructure and control the corrosion behavior of magnesium al oy. <br> OBJECTIVE:To explore the in vitro and in vivo degradation of Mg-Nd-Zn-Zr al oy as a degradable medical biomaterial. <br> METHODS:(1) In vitro static immersion test:The immersion tests were carried out at (37.0±0.5) thermostatic bath. Six Mg-Nd-Zn-Zr al oy samples and six pure magnesium samples were immersed in the 250 mL simulated body fluid and vibrated without agitation during immersion. After 3, 7 and 30 days static immersion, the samples were taken out from the simulated body fluid. Then the in vitro corrosion properties were evaluated using scanning electron microscope and energy dispersive spectrometer analysis. (2) In vivo animal experiment:After bone tunnel was established in the left femur of adult New Zealand rabbits, the Mg-Nd-Zn-Zr al oy rods were embedded in the Mg-Nd-Zn-Zr al oy group, titanium al oy rods were embedded in the titanium al oy group, and only bone tunnel was established in the sham-operated group. At 1, 2, 4, 8 weeks after implantation, an X-ray of the implanted region was taken to determine the location and the degradation behavior℃in a of Mg-Nd-Zn-Zr al oy. At 4, 8 weeks after implantation, the corrosion product and its element composition were observed using scanning electron microscope with an energy dispersive spectroscopy system.关键词
生物材料/材料生物相容性/镁合金/合金元素/降解/体外/体内分类
医药卫生引用本文复制引用
王勇平,蒋垚,毛琳,牛佳林,袁广银..可降解金属Mg-Nd-Zn-Zr镁合金的降解行为[J].中国组织工程研究,2013,(47):8189-8195,7.
