中国组织工程研究Issue(47)：8248-8254,7.DOI:10.3969/j.issn.2095-4344.2013.47.017
硅纳米线生物传感器与肿瘤标记物的检测
Silicon nanowire biosensor in detecting tumor markers
摘要
Abstract
BACKGROUND:Tumor markers are of great significance in early diagnosis of cancer, screening of high risk <br> group with cancer, differential diagnosis between benign and malignant tumors, judgment of cancer progression, evaluation of cancer therapeutic effect and prediction of cancer recurrence and prognosis. <br> OBJECTIVE:To realize the importance of tumor marker for cancer early diagnosis by introducing the working principle and clinical application of silicon nanowires biosensor in detecting tumor markers. <br> METHODS:The first author searched PubMed, CNKI and Google Scholar Databases to retrieve relevant articles about tumor marker, working principle and application of silicon nanowires biosensor published from 2003 to 2013. RESULTS AND CONCLUSION:Silicon nanowires biosensors with high sensitivity and without secondary marks show a good application prospect in detecting tumor markers. They have been used to detect tumor markers for prostate cancer, breast cancer, tumor markers of colorectal cancer, and primary liver cancer, and achieved an ideal limit of detection. However, due to the influence of debye length, most of detections can only be performed in the standard solution. There is a lack of the serum data of cancer patients.关键词
生物材料/生物材料综述/肿瘤标记物/纳米技术/硅纳米线/场效应晶体管/生物传感器/检测/国家自然科学基金分类
医药卫生引用本文复制引用
李增耀,王彤..硅纳米线生物传感器与肿瘤标记物的检测[J].中国组织工程研究,2013,(47):8248-8254,7.基金项目
国家自然科学基金(81371683/H1819)@@@@the National Natural Science Foundation of China, No.81371683/H1819 （81371683/H1819）
