中国组织工程研究Issue(47)：8255-8262,8.DOI:10.3969/j.issn.2095-4344.2013.47.018
二氧化钛纳米管的理论研究进展及临床实践
Research progress and clinical practice of TiO 2 nanotubes
摘要
Abstract
BACKGROUND:TiO2 nanotube array prepared by anodic oxidation is a nanomaterial having a perfect promising application at present. <br> OBJECTIVE:To review the research progress of TiO2 nanotube in clinic. <br> METHODS:The key words were TiO2 nanotubes, anodization, and biomaterials. We retrieved PubMed Database for articles concerning the clinical application of TiO2 nanotube published from January 2000 to June 2013. Repetitive and old studies were excluded, and 47 literatures were included for the review. <br> RESULTS AND CONCLUSION:The summarized results of the 47 literatures showed that TiO2 nanotube promoted the adhesion and proliferation of osteoblasts and mesenchymal stem cells including human. In vivo experiments verified that TiO2 nanotube could be used as a carrier to carry other drugs such as growth factor and antibiotics so as to promote the biocompatibility of the materials and to prevent bacterial adhesion. Results suggested that TiO2 nanotube contributed to the osseointegration of the material in vivo, and had a good biocompatibility.关键词
生物材料/生物材料综述/组织工程骨材料/纳米管/骨整合/生物相容性/药物载体/抗菌/国家自然科学基金分类
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张杭州,王琳,田昂,孙羽,白希壮,薛向欣..二氧化钛纳米管的理论研究进展及临床实践[J].中国组织工程研究,2013,(47):8255-8262,8.基金项目
国家自然科学基金面上项目(81071449,51002027)@@@@the National Natural Science Foundation of China (General Program), No.81071449,51002027 （81071449,51002027）
