中国组织工程研究Issue(48)：8374-8380,7.DOI:10.3969/j.issn.2095-4344.2013.48.013
辛伐他汀复合Bio-Oss修复兔下颌骨缺损
Simvastatin compounded with Bio-Oss repairs rabbit mandibular defects
摘要
Abstract
BACKGROUND:Studies have shown that simvastatin can promote bone formation, but there is stil controversial on the osteogenic mechanism and osteogenic effect. <br> OBJECTIVE:To explore the osteogenesis effect of the composite of simvastatin and Bio-Oss versus simple Bio-Oss material on the repair of rabbit mandibular defects. <br> METHODS:Twelve New Zealand white rabbits were selected to establish alveolar bilateral mandibular defects models. The composite of simvastatin and Bio-Oss was implanted randomly in one side of defect region;Bio-Oss was simply implanted in the other side of defect region. Both sides were covered with Bio-Gide bilayer col agen membrane. Four rabbits in each group were sacrificed at 4, 8 and 12 weeks after implantation, and the general observation X-ray film, oral cone-beam CT imaging observation and histopathologic study and quantitatively were conducted to quantitatively and qualitatively comparative analyze the alveolar bone formation in the graft region. <br> RESULTS AND CONCLUSION:At 4, 8 and 12 weeks after implantation, new bone formation was found and increased with time prolonging. With the gradual degeneration of high resistance fire Bio-Oss bone meal, the bone mineral density at different time points of the simvastatin composite Bio-Oss group was lower than that of the simple Bio-Oss group (P<0.05). The percentage of bone formation in the simvastatin composite Bio-Oss group was significantly higher than that in the simple Bio-Oss group (P<0.05). Simvastatin could accelerate Bio-Oss degradation and promote new bone formation in bone defects repairing.关键词
骨关节植入物/骨关节损伤基础实验/辛伐他汀/骨缺损修复/引导骨再生技术/Bio-Oss/Bio-Gide/下颌骨/口腔锥形束CT/新骨生成/省级基金分类
医药卫生引用本文复制引用
王洋,焦鑫,梁恒燕,葛振林..辛伐他汀复合Bio-Oss修复兔下颌骨缺损[J].中国组织工程研究,2013,(48):8374-8380,7.基金项目
甘肃省自然科学研究基金资助项目(1208RJZA209)@@@@Natural Science Foundation of Gansu Province, No.1208RJZA209 （1208RJZA209）
