中国组织工程研究Issue(50)：8691-8696,6.DOI:10.3969/j.issn.2095-4344.2013.50.012
增生性瘢痕中时序变化的骨形态发生蛋白及其受体
Expression of bone morphogenetic protein and its receptors in different stages of hypertrophic scar
摘要
Abstract
BACKGROUND:Bone morphogenetic proteins are associated with the formation and development of scars. Fibroblasts are closely related to the proliferation and maturation of scars. However, the expression of bone morphogenetic proteins in fibroblasts in different stage of hypertrophic scars remains poorly understood. <br> OBJECTIVE:To observe the expression of bone morphogenetic protein 2/4, bone morphogenetic protein 7, bone morphogenetic protein receptor IA in fibroblasts in different stage of hypertrophic scars. <br> METHODS:The immunohistochemical SP method was employed to detect the expression of bone morphogenetic protein 2/4, bone morphogenetic protein 7, bone morphogenetic protein receptor IA in fibroblasts in 20 cases of proliferative stage hypertrophic scar and 20 cases of maturation stage hypertrophic scar. Al samples were obtained from the Department of Plastic and Aesthetic Surgery, the People’s Hospital of Guangxi Zhuang Autonomous Region, China. <br> RESULTS AND CONCLUSION:The expression of bone morphogenetic protein 2/4 in fibroblasts in proliferative hypertrophic scars significantly elevated compared with mature hypertrophic scars (P<0.05). In various stages of hypertrophic scars, the expression of bone morphogenetic protein 7 and bone morphogenetic protein receptor IA in fibroblasts was not obviously different (P>0.05). Results demonstrated that bone morphogenetic protein 2/4 expression down-regulated during the development from proliferative stage to maturation stages in fibroblasts in hypertrophic scars. However, there was no change in the expression of bone morphogenetic protein 7 and bone morphogenetic protein receptor IA.关键词
组织构建/组织构建基础实验/皮肤黏膜组织构建/骨形态发生蛋白2/骨形态发生蛋白4/骨形态发生蛋白7/骨形态发生蛋白IA型受体/增生性瘢痕/成纤维细胞/增殖期/成熟期/省级基金分类
医药卫生引用本文复制引用
黄欣,韦海明,梁敏华,麦慧,朱格非,滕晓颦..增生性瘢痕中时序变化的骨形态发生蛋白及其受体[J].中国组织工程研究,2013,(50):8691-8696,6.基金项目
广西壮族自治区卫生厅课题(桂卫z2008041)@@@@the Project of the Health Department of Guangxi Zhuang Autonomous Region, No. z2008041 （桂卫z2008041）
