中国组织工程研究Issue(51)：8795-8800,6.DOI:10.3969/j.issn.2095-4344.2013.51.003
可降解高分子网状球囊及磷酸钙骨水泥椎体填充后的力学变化
Vertebral bodies implanted with biodegradable reticulated balloon and calcium phosphate cement:Changes in the vertebral biomechanics
摘要
Abstract
BACKGROUND:It has become a focus to look for new vertebral body fil ing materials which have the biomechanical property, biological activity and low cement leakage rate. <br> OBJECTIVE:To investigate the biomechanical characters and cement leakage rate of the vertebral bodies implanted with biodegradable reticulated bal oon and calcium phosphate. <br> METHODS:Thirty-two vertebral bodies from pigs were randomly divided to four groups. For A group, 2.5-3.0 mL polymethacrylate cement was injected into the body through a unilateral thoracic pedicle pathway;for B group, 2.5-3.0 mL calcium phosphate cement were injected by the same protocol;for C group, the biodegradable reticulated bal oons fil ed with 2.5-3.0 mL calcium phosphate cement were implanted;D group, including normal vertebral bodies, was designed as controls. Leakage of bone cement was observed in each group. The load-shift curves were recorded by an electronic universal testing machine (SCHENCK RSA-250). <br> RESULTS AND CONCLUSION:The stiffness and strength of A group were significantly higher than those of D group (P<0.05), and the stiffness and strength of B group were statistical y lower than those of D group (P<0.05). The stiffness and strength of C group, otherwise, were similar with those of D group (P>0.05). Cement leakage rate of C group was lower than that of A or B group (P<0.05). Vertebral bodies implanted with biodegradable reticulated bal oons may lead to similar biomechanical characters as the normal vertebral bodies and reduce the cement leakage rate.关键词
生物材料/组织工程骨材料/骨水泥/椎体成形术/椎体后凸成形术/可降解球囊/生物力学/国家自然科学基金分类
医药卫生引用本文复制引用
彭湘涛,刘训伟,李敏,钟建,魏岱旭,何丹农,孙钢..可降解高分子网状球囊及磷酸钙骨水泥椎体填充后的力学变化[J].中国组织工程研究,2013,(51):8795-8800,6.基金项目
国家自然科学基金资助(51073173)@@@@the National Natural Science Foundation of China, No.51073173 （51073173）
