中国组织工程研究Issue(51)：8920-8927,8.DOI:10.3969/j.issn.2095-4344.2013.51.022
支架植入与内膜剥脱治疗颈动脉狭窄的疗效与安全性评价
Carotid artery stenting or carotid endarterectomy for treatment of carotid stenosis:Effectiveness and safety
辛海 1白超 1王洋 1李新喜 1罗军 1田野 1张克瑞1
作者信息
- 1. 新疆医科大学第一附属医院血管甲状腺外科，新疆维吾尔自治区乌鲁木齐市 830054
- 折叠
摘要
Abstract
BACKGROUND:Large randomized trials have demonstrated carotid endarterectomy or stenting for symptomatic and asymptomatic extracranial carotid stenosis is effective. <br> OBJECTIVE:Using the meta analysis method, to evaluate efficacy and safety of carotid stenting and carotid endarterectomy for the treatment of carotid stenosis. <br> METHODS:Computer-based retrieval of databases both at home and abroad was performed for randomized control ed trials related to carotid stenting and carotid endarterectomy for the treatment of carotid stenosis. According to exclusion criteria, literature screening was done fol owed by quality evaluation. Then, the enrol ed literatures were analyzed by Cochrane col aboration with RevMan5.0 Meta analysis software. <br> RESULTS AND CONCLUSION:There were 14 enrol ed studies, including 7 693 patients among whom, 3 835 cases were in stenting group and 3 858 in carotid endarterectomy group. Compared with the carotid endarterectomy group, the stroke event rate within 30 days postoperatively, death and stroke event rate within 30 days postoperatively, myocardial infarction event rate within 1 year postoperatively and non-disabling stroke event rate within 30 days postoperatively were higher in the stenting group (P ≤0.000 1);the myocardial infarction event rate within 30 days postoperatively was lower in the stenting group (P=0.001 0). There were no significant differences in the death event rate and disabled stroke event rate within 30 days postoperatively between the two groups. These two treatments are complementary rather than antagonistic. We should optimize the treatment choice based on the comprehensive analysis of each patient's condition.关键词
生物材料/生物材料循证医学/颈动脉狭窄/颈动脉支架植入/颈动脉内膜切除/随机对照试验/Meta分析/脑卒中分类
医药卫生引用本文复制引用
辛海,白超,王洋,李新喜,罗军,田野,张克瑞..支架植入与内膜剥脱治疗颈动脉狭窄的疗效与安全性评价[J].中国组织工程研究,2013,(51):8920-8927,8.
