中国组织工程研究Issue(52)：9095-9100,6.DOI:10.3969/j.issn.2095-4344.2013.52.025
老年髋部骨折的预后：白蛋白、淋巴细胞、血红蛋白之效应
Prognosis of hip fractures in elderly patients:Effects of albumin, lymphocyte and hemoglobin
摘要
Abstract
BACKGROUND:Studies have shown that malnutrition was associated with death of elder people after fracture of hip, but there were no above-mentioned reports in China. <br> OBJECTIVE: To retrospectively analyze the relationship of blood albumin, total lymphocyte count and hemoglobin levels to prognosis when elder patients with fracture of hip were on admission. <br> METHODS:130 elderly patients with hip fractures aged ≥ 70 years were included underwent either total hip arthroplasty or bipolar arthroplasty. Admission serum albumin, total lymphocytecount and hemoglobin levels were recorded. The patients were fol owed up for 1 year or til the death. Survival data were available in 92 patients. Rates of survival were calculated by the Kaplan-Meier method and the Log-Rank test. Cox proportional hazard regression model received prognostic multivariate analysis. <br> RESULTS AND CONCLUSION:Of the 92 patients, albumin<35 g/L in 20 cases (22%), total lymphocyte count<1.5×106/L in 67 cases (73%), and hemoglobin<120 g/L in 56 cases (61%). Kaplan-Meier method showed that the survival rate of patients with normal albumin (≥ 35 g/L) was significantly higher than those with reduced albumin (<35 g/L) (P<0.01). No significant difference was detected in the survival rate of patients with normal total lymphocyte count (≥ 1.5×106/L) and reduced total lymphocyte count (<1.5×106/L) (P>0.05). The survival rate of patients with normal hemoglobin (≥ 120 g/L) was significantly higher than those with decreased hemoglobin (<120 g/L) (P <0.05). Cox multivariate analysis displayed that albumin decrease is an independent prognostic factor for death of patients with hip fracture. Results indicated that the prognosis of elder patients with hip fracture was strongly associated with their nutritional conditions. Albumin and hemoglobin levels at admission can be considered as important indexes for judging patient’s prognosis.关键词
骨关节植入物/骨与关节临床实践/髋部骨折/白蛋白/淋巴细胞数/血红蛋白/死亡率/国家自然科学基金Key words
hip fracture/albumin/lymphocyte/hemoglobin/mortality分类
医药卫生引用本文复制引用
王振恒,方永超,阚翔翔,郭亭,赵建宁..老年髋部骨折的预后：白蛋白、淋巴细胞、血红蛋白之效应[J].中国组织工程研究,2013,(52):9095-9100,6.基金项目
国家自然科学基金项目(81000792)*；江苏省临床药学科技专项资助(BL2012002)*Funding:the National Natural Science Foundation of China, No.81000792* （81000792）
the Clinical Pharmacy Technology Project of Jiangsu Province, No. BL2012002* （）
