中国组织工程研究Issue(1)：143-148,6.DOI:10.3969/j.issn.2095-4344.2014.01.024
应用于缺血缺氧性脑病治疗的神经干细胞移植：现实与未来
Neural stem cell transplantation:its actuality and future used for treatment of hypoxic-ischemic encephalopathy
摘要
Abstract
BACKGROUND:Many studies have showed that neural stem cells therapy is a new strategy for hypoxic-ischemic encephalopathy. <br> OBJECTIVE:To review and analyze the status of research, transplantation strategies and mechanism of neural stem cells therapy for treatment of hypoxic-ischemic encephalopathy. <br> METHODS:A computer-based retrieval was performed in PubMed and CNKI database to search papers published from August 2000 to August 2013 using the key words of“hypoxic-ischemic encephalopathy, neural stem cells”in English and Chinese. The papers with objective-independent and repetitive contents were excluded, and final y 39 papers were included for final analysis. <br> RESULTS AND CONCLUSION:Neural stem celltransplantation can promote recovery of neurological function, which brings new hope to hypoxic-ischemic encephalopathy patients. But the study is at a primary stage and limited in laboratory. There are many critical factors that hinder the clinical transplantation, such as delivery path, transplantation time, single or combined transplantation, mechanisms of action. Application of neural stem cells requires further investigation.关键词
干细胞/移植/神经干细胞/缺血缺氧性脑病/神经功能/血管移植/安全性/国家重点基础研究发展计划(973计划)Key words
stem cells/neural stem cells/hypoxia, brain/stem celltransplantation分类
医药卫生引用本文复制引用
杨坦,刘华,王肇光,高济凡,肖东杰,汪运山..应用于缺血缺氧性脑病治疗的神经干细胞移植：现实与未来[J].中国组织工程研究,2014,(1):143-148,6.基金项目
国家青年科学基金项目(81200950)；济南市青年科技明星计划(20100316)；国家重点基础研究发展计划(973计划)(2012CB966503和2012CB966504)@@@@the National Youth Science Foundation of China, No.81200950 （81200950）
Youth Scientific Star Program of Jinan City, No.20100316 （）
the National Program on Key Basic Research Projects (973 Program), No.2012CB966503,2012CB966504 （973 Program）
