中国组织工程研究Issue(2)：245-250,6.DOI:10.3969/j.issn.2095-4344.2014.02.014
骨代谢指标与骨关节炎及绝经后骨质疏松症的关系
Correlation of bone metabolic index with osteoarthritis and postmenopausal osteoporosis
摘要
Abstract
BACKGROUND:Increasingly studies report that the normal balance of bone metabolism may be destroyed in the case of postmenopausal osteoporosis or osteoarthritis. The concrete metabolic process of bone turnover could be revealed sensitively by measuring the bone turnover markers in the serum or urine. <br> OBJECTIVE:To study the bone density and bone metabolic index of knee osteoarthritis (KOA) and postmenopausal osteoporosis (PMO), and to discuss the characteristics of bone density and bone metabolic index in KOA and PMO. <br> METHODS:A total of 248 postmenopausal women were detected for bone mineral density and knee X-ray. Final y 180 patients were included in this study and were divided into three groups:KOA group, PMO group, and control group. The levels of bone turnover markers (bone alkaline phosphatase, bone gla protein, col agen type I cross-linked C-telopeptide, and tartrate-resistant acid phosphatase 5b) in serum from the participants were measured. The correlation between bone turnover markers and the disease progression was analyzed by Logistic regression analysis. <br> RESULTS AND CONCLUSION:The bone mineral density in the KOA group was higher than the control group but col agen type I cross-linked C-telopeptide was lower. The levels of bone gla protein, col agen type I cross-linked C-telopeptide, and tartrate-resistant acid phosphatase 5b in serum from PMO group were higher than the control group. The decrease of col agen type I cross-linked C-telopeptide was associated with the incidence of KOA, and the increases of bone gla protein, col agen type I cross-linked C-telopeptide, and tartrate-resistant acid phosphatase 5b were associated with the incidence of PMO. The lower bone absorption can be seen in postmenopausal women with KOA. PMO patients showed a higher bone turnover rate. The difference of bone metabolism between patients with KOA and PMO led to negative relationship of bone mineral density. The serum levels of bone gla protein, col agen type I cross-linked C-telopeptide, and tartrate-resistant acid phosphatase 5b can assist clinical diagnose and therapeutic effect detection of both KOA and PMO.关键词
组织构建/骨组织工程/骨质疏松/膝骨关节炎/绝经/骨密度/骨代谢指标/骨钙素/Ⅰ型胶原交联C末端肽Key words
osteoporosis, postmenopausal/osteoarthritis, knee/bone mineral density/alkaline phosphatase分类
医药卫生引用本文复制引用
赵玺,赵文,孙璟,彭海洲,李毅,赵太茂,熊中伟..骨代谢指标与骨关节炎及绝经后骨质疏松症的关系[J].中国组织工程研究,2014,(2):245-250,6.基金项目
北京市丰台区基金资助项目(2012-202)@@@@a grant by Fengtai District Science and Technology Foundation of Beijing, No.2012-202 （2012-202）
