中国组织工程研究Issue(2)：314-321,8.DOI:10.3969/j.issn.2095-4344.2014.02.025
脑水通道蛋白的分布、功能及调控机制
Distribution, function and regulation mechanism of aquaporin in the brain
摘要
Abstract
BACKGROUND:The aquaporin (AQP), mainly AQP1, AQP4 and AQP9, are expressed in mammalian brain, while the others are sporadical y expressed. There is no evidence concerning the distribution, function and regulation mechanism of AQP in the brain. <br> OBJECTIVE:To comprehensively analyze the research progress of the distribution, function and regulation mechanism of AQP in maintaining normal physiological function of the brain. <br> METHODS:An online retrieval of PubMed database and CNKI database between January 1980 and July 2013 was performed for articles on the distribution, function and regulation mechanism of AQP, with the key words of“AQP1, AQP4, AQP9, function, brain, adjusting mechanism”in English and Chinese. A total of 163 papers were screened out and 85 of them met the inclusive criteria. <br> RESULTS AND CONCLUSION:The existing studies about the expression, function and regulating mechanism of AQP1, AQP4 and AQP9 in the brain can be summarized as the fol owing three aspects: (1) AQP1 is expressed in the choroid plexus and participates in forming cerebrospinal fluid;in other types of cells, gas micromolecules CO 2 , NO, NH 3 and O 2 also cross through AQP1. (2) AQP4 is mainly expressed in the astrocytes, ependymal foot process and gelatin membranes, which can help the water in and out of the brain tissue, accelerate glial cellmigration and change neural activity. (3) AQP9 is mainly distributed in astrocytes and catecholamine neurons, the main function is involved in energy metabolism in the brain. Therefore, AQP is the key for water transport in the brain. Understanding the distribution, function and regulation mechanism of AQP wil play an important role in the treatment of brain diseases. The regulatory mechanism on the expression of AQPs in normal pathology and related disease remains unclear and related molecular signal pathway needs further exploration.关键词
组织构建/组织工程/水通道蛋白1/水通道蛋白4/水通道蛋白9/脑/能量代谢/调节机制/国家自然科学基金Key words
aquaporin 1/aquaporin 4/brain/energy metabolism/review分类
医药卫生引用本文复制引用
刘健锋,丁艳平,王建林,邵宝平..脑水通道蛋白的分布、功能及调控机制[J].中国组织工程研究,2014,(2):314-321,8.基金项目
国家自然科学基金项目(31000190，31060141)；中央高校基本科研业务费专项资金资助项目(lzujbky-2012-102)@@@@the National Natural Science Foundation of China, No.31000190,31060141 （31000190，31060141）
Fundamental Research Funds for the Central Universities, No. lzujbky-2012-102 （）
