中国组织工程研究Issue(3)：406-411,6.DOI:10.3969/j.issn.2095-4344.2014.03.013
多微孔多聚糖止血粉应用于软组织创伤性出血
Hemostasis effects of microporous polysaccharide hemostatic powder on soft tissue trauma
摘要
Abstract
BACKGROUND:A cross-emulsification patented product of microporous polysaccharide hemostatic powder was prepared using potatoes as raw material with independent intel ectual property rights. <br> OBJECTIVE:To observe hemostasis effects of microporous polysaccharide hemostatic powder on soft tissue trauma. <br> METHODS:A wound, about 3 cm long and 0.5 cm deep, was made on the abdominal soft tissue of rabbits in the experimental group 1, and then microporous polysaccharide hemostatic powder, 1.0-2.0 g, was sprayed directly on the wound. In the experimental group 2, a wound, about 3.0 cm long and 1.0 cm deep, was made on the abdominal soft tissue of rabbits, and then microporous polysaccharide hemostatic powder, 1.0-2.0 g, was sprayed directly on the wound. Another rabbits with untreated wound served as controls. <br> RESULTS AND CONCLUSION:Microporous polysaccharide hemostatic powder formed a“pasty gel”covering the bleeding wound that achieved hemostatic effect. The bleeding time was (15.25±1.04) seconds in the experimental group 1 and (11.25±1.89) seconds in the experimental group 2. The marked effective and effective rates for hemostasis were 87.5%and 100%, respectively. In the control group, the bleeding time was more than 5 minutes. Hematoxylin-eosin staining showed mild muscle edema, vasodilatation of smal blood vessels, and few scattered endoplasmic neutrophils infiltrated at 24 hours after treatment with microporous polysaccharide hemostatic powder;til the 7th day, inflammation subsided, mild fibrosis was visible on muscle tissue surface, the hemostatic powder was completely absorbed, the wound tissue was close to the normal tissue, and there were no significant changes in muscle cells. These findings suggest that microporous polysaccharide hemostatic powder can be used for hemostasis of soft tissue trauma.关键词
生物材料/材料相容性/马铃薯淀粉/止血材料/多微孔多聚糖/实验/家兔Key words
biocompatible materials/hemostasis/soft tissue injuries/Solanum tuberosum分类
医药卫生引用本文复制引用
史跃,杜宝堂,何远清,殷文静..多微孔多聚糖止血粉应用于软组织创伤性出血[J].中国组织工程研究,2014,(3):406-411,6.基金项目
镇江市政府331工程资助 （）
