中国组织工程研究Issue(3)：446-451,6.DOI:10.3969/j.issn.2095-4344.2014.03.019
制备软骨组织工程支架的方法
Fabrication technologies of tissue-engineered cartilage scaffolds
摘要
Abstract
BACKGROUND:Cartilage tissue engineering scaffold is a substitution for extracellular matrix, and there is a great significance on the shape and pore structure of the scaffold. <br> OBJECTIVE:To retrospectively focus on the fabrication technology of three-dimensional porous cartilage tissue engineering scaffolds. <br> METHODS:The first author searched PubMed, ELSEVIER SCIENCEDIRECT, Wanfang and CNKI databases (2000/2013) to retrieve relevant articles about the fabrication technology tissue-engineered cartilage scaffolds. The key words were“cartilage tissue engineering;scaffolds;fabrication”in English and Chinese, respectively. RESULTS AND CONCLUSION:The fabrication technologies of three-dimensional porous cartilage tissue <br> engineering scaffolds are as fol ows:Phase separation/freeze-drying, hydrogels, rapid prototyping manufacturing, electrospinning, solvent casting/particulate leaching, gas foaming. The current cartilage studies have demonstrated that the pore size has a significance on the regeneration of the cartilage tissue, the pore size ranging from 100-250μm al ows for the regeneration of bone and cartilage tissue. The scaffold fabricated by the solvent casting/particulate leaching and gas foaming technology at a pore size of 100-250μm is suitable for the bone and cartilage tissue regeneration. To obtain the adequate biological and mechanical properties, researchers usual y combine a variety of methods to fabricate the cartilage tissue engineering scaffolds.关键词
生物材料/软骨生物材料/软骨组织工程/制备方法/支架材料/多孔支架/辽宁省自然科学基金Key words
biocompatible materials/cartilage/tissue engineering/stents分类
医药卫生引用本文复制引用
倪硕,李澎,张卫国,李鹏声,贵浩然..制备软骨组织工程支架的方法[J].中国组织工程研究,2014,(3):446-451,6.基金项目
辽宁省自然科学基金资助项目(2013023034)，项目负责人李澎 （2013023034）
