中国组织工程研究Issue(5)：675-680,6.DOI:10.3969/j.issn.2095-4344.2014.05.004
针刺胃扩张模型大鼠内关、足三里等穴位下丘脑室旁核相关神经元的反应
Response of gastric-related neurons in the hypothalamic paraventricular nucleus to acupuncture at Neiguan and Zusanli in a rat model of gastric distension
摘要
Abstract
BACKGROUND:Previous studies concerning neuromechanism of acupuncture for regulating gastric function mainly focused on peripheral nerve, involving in central nervous system. In particular, there are few studies addressing higher central nervous system. <br> OBJECTIVE:To explore the effects of acupuncture at Neiguan (PC6) and Zusanli (ST36) on gastric-related neurons in the hypothalamic paraventricular nucleus. <br> METHODS:Using microelectrode extracellular recording technique, gastric related neurons in the paraventricular nucleus were found in gastric distension rats. Stimulation was conducted for 30 seconds by hand acupuncture at Neiguan and Zusanli. The effects of acupuncture on gastric-related neurons in the paraventricular nucleus were observed. <br> RESULTS AND CONCLUSION:The discharge of 109 neurons in the hypothalamic paraventricular nucleus of 60 rats was recorded. A total of 56 gastric-related neurons of the 109 neurons were observed. The number of neurons response to acupunctures at Zusanli, Neiguan, Pishu (BL20) and Weishu (BL21) were respectively 44, 47, 29, and 33, with the reaction proportion of 78.57%, 83.47%, 51.79%and 58.93%. Results suggested that there exist gastric distension stimulation and acupuncture stimulations from neurons soma to visceral reaction in the hypothalamic paraventricular nucleus, which simultaneously participates in the regulation of acupuncture on the gastric function.关键词
实验动物/组织构建/下丘脑室旁核/胃相关神经元/针刺刺激/国家自然科学基金Key words
paraventricular hypothalamic nucleus/neurons/gastric dilatation/vagus nerve/acupuncture points分类
医药卫生引用本文复制引用
陈姝,雍春燕,陈恒,初晓,张超,谭程,叶兰,李江山..针刺胃扩张模型大鼠内关、足三里等穴位下丘脑室旁核相关神经元的反应[J].中国组织工程研究,2014,(5):675-680,6.基金项目
国家自然科学基金面上项目课题(81273677) （81273677）
