中国组织工程研究Issue(10)：1635-1640,6.DOI:10.3969/j.issn.2095-4344.2014.10.025
干细胞移植治疗糖尿病肾病：可能可行与应用
Stem cell transplantation for diabetic nephropathy:possibility, feasibility and application
何晏清 1杨萍1
作者信息
- 1. 湖北医药学院附属太和医院，湖北省十堰市 442000
- 折叠
摘要
Abstract
BACKGROUND:To control blood glucose, blood pressure, blood lipids and inhibit the rennin-angiotensin system is the main idea focused on the treatment of diabetic nephropathy, but the curative effect is unsatisfactory. Hemodialysis and kidney transplantation are suitable for serious cases, however, which is restricted because of the limited source of kidneys and high cost. Regenerative medicine research based on stem cells brings a new hope for treatment of diabetic nephropathy. OBJECTIVE:To comprehensively analyze the mechanism underlying different sources of stem cells for treatment of diabetic nephropathy and the clinical implications. METHODS:Papers addressing stem cells for the treatment of diabetic nephropathy were retrieved by computer in CNKI database and PubMed database from January 2005 to August 2013 with the key words“embryonic stem cells, bone marrow mesenchymal stem cells, induced pluripotent stem cells, diabetic nephropathy"in Chinese and English. Papers published recently or in journals with high impact factor were selected. A total of 60 papers were included for review. RESULTS AND CONCLUSION:Embryonic stem cells, bone marrow mesenchymal stem cells, induced pluripotent stem cells have the potential to differentiate into renal histiocytes. A large numbers of experimental studies have shown that stem cells transplantation has a positive effect on recovery of injured kidney. Stem celltransplantation can provide a novel therapy for diabetic nephropathy.关键词
干细胞/移植/胚胎干细胞/骨髓间充质干细胞/诱导性多能干细胞/糖尿病肾病Key words
stem cells/diabetic nephropathies/mesenchymal stem cells/multipotent stem cells分类
医药卫生引用本文复制引用
何晏清,杨萍..干细胞移植治疗糖尿病肾病：可能可行与应用[J].中国组织工程研究,2014,(10):1635-1640,6.
