中国组织工程研究Issue(12)：1907-1913,7.DOI:10.3969/j.issn.2095-4344.2014.12.017
自组装多肽纳米纤维水凝胶在细胞三维培养中的应用及特征
Application and characteristics of self-assembling peptide nanofiber hydrogel in three-dimensional cell culture systems
摘要
Abstract
BACKGROUND:Self-assembling peptide scaffolds have attracted much more attention among three dimensional biomaterials due to its biocompatibility, biodegradation, and tailor-made properties. <br> OBJECTIVE:To review the structure and design of functionalized self-assembling RADA peptide, and the recent advances in the use of RADA self-assembling peptide for three-dimensional cel culture in cel therapy applications. <br> METHODS:Total 224 literatures related to self-assembling peptide and tissue engineering from PubMed, Web of Science and CNKI databases were screened out for this review. The keywords were“self-assembly peptide, tissue engineering”in English and Chinese, respectively. Final y 48 of 224 articles about the design, fictionalization, and three-dimensional cel culture of peptide scaffolds were included in this review. <br> RESULTS AND CONCLUSION:Self-assembling peptide could undergo spontaneous assembly into wel-ordered interwoven nanofibers in water and rapidly form hydrogel, which physical y mimics the architecture of natural extracel ular matrix to ensure a real three-dimensional microenvironment for cel s. In terms of bio-function, this material can be tailor-made with various bioactive short peptide motifs to promote cel adhesion, proliferation, and differentiation.关键词
生物材料/纳米生物材料/自组装多肽/水凝胶/纳米纤维/三维培养/生物材料综述Key words
biocompatible materials/peptides/hydrogel/cel s/nanofibers分类
医药卫生引用本文复制引用
刘茜,王秀梅..自组装多肽纳米纤维水凝胶在细胞三维培养中的应用及特征[J].中国组织工程研究,2014,(12):1907-1913,7.基金项目
江苏省高校自然科学研究面上项目(13KJB430019)；中国博士后科学基金(2013M541724)；清华大学自主科研计划(20121087982)@@@@Funding:Natural Science Foundation of the Higher Education Institutions of Jiangsu Province, No.13KJB430019 （13KJB430019）
China Postdoctoral Science Foundation, No.2013M541724 （）
Tsinghua University Initiative Scientific Research Program, No.20121087982 （）
