现代医药卫生Issue(7)：993-996,4.DOI:10.3969/j.issn.1009-5519.2014.07.014
长沙地区支原体感染情况及耐药性变迁
Epidemiology and drug resistance of mycoplasma in Changsha area
摘要
Abstract
Objective To comprehend the new epidemiological characteristics of mycoplasma in Changsha districts dur-ing 2008-2012,in order to guide clinical rational drug use and control the occurrence of nosocomial infection. Methods Totally 1 447 examinees with mycoplasma inspection in outpatient department and inpatient department in Hunan Provincial People′s Hospital,Changsha Municipal First Hospital and the Second Xiangya Hospital of Central South University during 2008-2012 were selected. Mycoplasma cultivation , determination and drug sensitive test were conducted on male urethral secretion ,prostatic fluid,seminal fluid and female cervical wecretion before the application of antibiotic therapy. Results (1)Male seminal fluid had the highest detection rate of 45.5%(15/33),followed by urethral secretion(30.8%,77/250). (2)The highest infection rate ap-peared among people aged 20-<50(50.4%,729/1 447),and the mycoplasma infection rate among the peoples aged 40-<50 was on the rise. (3)The simple Ureaplasma Urealyticum(Uu) infection rate was 5.2%(75/1 447) in male and 32.2%(466/1 447) in fe male,the simple mycoplasma hominis(Mh) infection rate was 0.3%(4/1 447) in male and 0.8%(12/1 447) in female,and the mixed infection rate of Uu and Mh was 1.6%(23/1 447) in male and 14.2%(206/1 447) in female. (4)Among the 786 positive specimen during 2008-2012,the sensitive rate to minocycline was 87.3%,87.7%,90.1%,91.8% and 93.0% respectively;to doxycycline was 85.8%,90.1%,89.6%,86.0%and 92.5%respectively;ciprofloxacin was 2.2%,3.1%,3.7%,7.7%and 1.9%re-spectively;sparfloxacin was 46.3%,44.4%,35.8%,32.9% and 25.3% respectively;roxithromycin was 21.6%,16.0%,21.6%, 27.3% and 15.0% respectively;azithromycin was 26.9%,20.4%,34.3%,45.5% and 36.6% respectively;clarithromycin was 70.1%,67.9%,52.2%,63.6%and 59.2%respectively. Conclusion (1)The detection specimen of mycoplasma in Changsha area is recommended for male urethral secretion and femal cervical wescretion. (2)Mycoplasma infection in Changsha areas were prone to the groups aged 20-<40,and the infection rate of mycoplasma in groups aged 0-<20 and 40-<50 was on rise. (3)Mycoplas-ma infection in Changsha is mainly simple Uu. (4)Minocycline and doxycycline are recommended as the first choice drug in the treatment of mycoplasma infection in Changsha area.关键词
支原体感染/流行病学/支原体属/大环内酯类/药物耐受性/湖南Key words
Mycoplasma infections/epidemiology/Mycoplasma/Macrolides/Drug tolerance/Hunan引用本文复制引用
陈俞霖,杨玉洁,刘天星,雷娟,王力文,徐明,周佩茹,林雪迟..长沙地区支原体感染情况及耐药性变迁[J].现代医药卫生,2014,(7):993-996,4.基金项目
长沙医学院大学生研究性学习和创新性实验计划资助项目（201209）。 （）
