心脑血管病防治Issue(1)：8-10,3.DOI:10.3969/j.issn.1009-816x.2014.01.04
基因芯片法检测浙江省部分汉族人群乙醛脱氢酶2基因多态性
Gene Polymorphism of Aldehyde Dehydrogenase 2 (ALDH2) Detecting by Gene Chip in Part of the Han Population in Zhe-jiang Province
吕远栋 1胡细连 1陶萍华 1徐伟红 1王雅珍 1吕晓玲1
作者信息
- 1. 310013 浙江医院 浙江省老年医学重点实验室 浙江省老年病研究所
- 折叠
摘要
Abstract
Objective To investigate the ALDH2 gene polymorphism in part of Han population in Zhejiang province.Methods With 1370 blood samples of Han population in Zhejiang province ,the specific fragment of ALDH2 gene exon 12 were amplified using gene chip technique to judge the genotypes.Results The frequency distribution of ALDH2 mutant alleles was 44.5% in Han population of Zhejiang province.There was no statistical differences between the distributions of ALDH 2 genotype frequencies of the population in Zhejiang province compared with that in Shanghai district ;while there was a difference when compared to the population of Luoyang population.Conclusions The percentage of ALDH2 gene variant in Han population of Zhejiang province was nearly half ,which showed that the percentage of people lacking ALDH2 enzyme activity was nearly half ;and there was a regional difference of ALDH2 gene polymorphism between north and south in Chinese Han population.关键词
基因芯片/乙醛脱氢酶2/基因多态性Key words
Gene chip/Aldehyde dehydrogenase 2/Gene polymorphism分类
医药卫生引用本文复制引用
吕远栋,胡细连,陶萍华,徐伟红,王雅珍,吕晓玲..基因芯片法检测浙江省部分汉族人群乙醛脱氢酶2基因多态性[J].心脑血管病防治,2014,(1):8-10,3.
