心脑血管病防治Issue(1)：19-21,3.DOI:10.3969/j.issn.1009-816x.2014.01.08
急性冠脉综合征患者短期大剂量瑞舒伐他汀治疗安全性和有效性的研究
The Efficacy and Safety of Short Term Intensive Rosuvastatin Therapy in Acute Coronary Syndrome
来蕾 1朱刚杰 1王宁夫 1李虹 1童国新 1杨建敏 1叶显华 1周亮 1潘浩1
作者信息
摘要
Abstract
Objective To evaluate the efficacy and safety of large doses intensive rosuvastatin treatment in short_term among the pa-tients with acute coronary syndrome (ACS ) during hospitalization.Methods A total of 131 ACS patients were enrolled into this study.They were randomly divided into the intensive group and conventional group.The patients in the intensive group were given 20mg ro-suvastatin as soon as admission ,20mg rosuvastatin every night during hospitalization.The patients in the general group were given 10mg every night during hospitalization.All the patients were given the biochemical indexes detection both on admission and after one week’s treatment.Results Age ,gender ,complications ,smoking ,overweight ,creatinine(Cr) ,creatine kinase(CK) ,and glomeru-larfiltrationrate(GFR)weresimilarbetweentwogroups (P>0.05).Levelsofbasicalanineaminotransferase (ALT)inconventional group were higher than that in intensive group.After one week’s treatment ,alanine aminotransferase (ALT) and aspartate amino-transferase (AST ) were higher in both groups ,which had a significantly difference than before ( P<0.05 ) ,but still in normal range.Compared with 10mg group ,there was no significant increase in the proportion of 3_times increased in ALT ,and AST in 20mg group.No differences were found in CK ,Cr and GFR after one week’s therapy in both groups.After one week’s therapy ,blood total choles-terol ,triglycerides and LDL cholesterol were lower than before in both groups ,but LDL_C of intensive treatment were significantly lower than conventional treatment.HDL_C had no significantly differences in conventional group but significantly higher in the inten-sive group after one week’s treatment.Conclusions The 20mg short_term intensive rosuvastatin treatment is as safe as the 10mg gen-eral treatment ,and effectively reduce the lipid and cholesterol levels ,and increase the high density lipoprotein.关键词
瑞舒伐他汀/急性冠脉综合征/血脂Key words
Rosuvastatin/Acute coronary syndrome/Blood lipid分类
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来蕾,朱刚杰,王宁夫,李虹,童国新,杨建敏,叶显华,周亮,潘浩..急性冠脉综合征患者短期大剂量瑞舒伐他汀治疗安全性和有效性的研究[J].心脑血管病防治,2014,(1):19-21,3.
