摘要
Abstract
Objective To systematically assess the curative effect of thyroxine in patients with heart failure complicating low T 3 syn-drome.Methods Retrieving databases including Pubmed ,Web of Science ,Cochrane Library ,CBM ,WanFang database and VIP database.The retrieval time limited from the foundation of database to June 2013.Meantime ,references of articles were searched.According to the inclusion criterion ,relevant articles were screened.After extracting data ,quality of data was assessed ,and meta_analysis was performed by RevMan 5.2.Results A total of 11 RCTs involving 662 patients were included.The result of meta_analyses showed that ,compared with the control group ,after short_term treatment with thyroxine ,left ventricular ejection fraction (LVEF) and cardiac output (CO ) of the treatment group obviously increased (MD=5.16 ,95% CI=3.11~7.21 , P<0.01;MD=0.55 ,95%CI=0.33~0.7 P<0.01 ).Besides ,the evaluation index of ventricular diastolic function E/A was improved and left ventricular end diastolic diameter (LVDD ) was decreased (MD=0.22 ,95% CI=0.09~0.34 ,P<0.01;MD= -4.14 ,95% CI= -6.66~ -1.61 ,P<0.01 ).Conclusions Thyroxine based on routine treatment can improve the heart ejection function and the ventricular dias-tolic function for patients with heart failure complicating low T 3 syndrome.关键词
甲状腺激素/心力衰竭/低T3综合征/Meta分析Key words
Thyroid hormones/Heart failure/Low T3 syndrome/Meta_Analysis分类
医药卫生
