心脑血管病防治Issue(2)：105-107,3.DOI:10.3969/j.issn.1009-816x.2014.02.06
磺脲类药物对兔心肌缺血再灌注损伤后适应影响的研究
Effects of Sulfonylurea on Myocardial Ischemia_reperfusion Injury in Rabbits
摘要
Abstract
Objective To explore the effects of sulfonylurea on myocardial ischemia_reperfusion injury in rabbits.Methods 30 healthy New Zealand rabbits were randomly divided into 5 groups:(1 )sham operation group (coronary artery ligation ,CAL );(2 ) ischemia reperfusion injury group (IRI) ,ischemia for 45 minutes and reperfusion for 2 hours;(3) postconditioning (Post C) group ,after is-chemia for 45 minutes ,30 seconds reperfusion ,30 seconds occlusion of coronary artery and repeated for 3 times ,then reperfusion for 2 hours;(4) glimepiride group ,IV 0.2mg/kg of glimepiride through periphery vein ,then the same process conducted as Post C group;(5 )glibenclamide group ,IV 0.5mg/kg of glibenclamide through periphery vein ,then the same process conducted as Post C group.The infarct size and the content of cTnI were measured at the end of experiment.Results The content of cTnI in sham opera-tion group was significantly lower compared with the other groups.The content of cTnI in Post C and Glimepiride group were signifi-cantly lower than IRI and glibenclamide groups ( P< 0.01 ). There was no significant difference between Post C and glimepiride group ,IRI and glibenclamide group.The infarct size of Post C and glimepiride group were significantly smaller compared with the IRI and glibenclamide group ;there was no difference between Post C group and glimepiride group ,and there was also no difference be-tween IRI group and glibenclamide group.Conclusions Postconditioning may provide myocardial protection in rabbits in IRI.This ef-fect can be abolished by glibenclamide but not by glimepiridei .关键词
心肌缺血再灌注损伤/后适应/磺脲类Key words
Myocardium ischemia_reperfusion injury/Postconditioning/Sulfonylurea分类
医药卫生引用本文复制引用
盛西陵,祝玉娟,徐文博,唐关敏..磺脲类药物对兔心肌缺血再灌注损伤后适应影响的研究[J].心脑血管病防治,2014,(2):105-107,3.基金项目
浙江省科技厅项目 （）
