湖北科技学院学报（医学版）Issue(6)：461-462,2.
EGCG通过 PICK1抑制可卡因小鼠的自发活动机制研究
EGC G Inhibits Cocaine Induced Locomotor Activity via PICK1
摘要
Abstract
Objective The aim of this study was to examine the effect of EGCG on cocaine induced lo-comotor activity in mice ,and to explore its mechanism of action .Methods EGCG was pretreated before cocaine which was used by intraperitoneal injection .Locomotor activity was detected by behavioral test and the expres-sion of PICK1 protein in the nucleus accumbens ( NAc) was tested by Western blot .Results EGCG can inhibit cocaine induced locomotor activity ,and reduce the expression of PICK 1 protein in NAc.Conclusion EGCG may be important pharmocological effect to prevent cocaine induced drug abuse ,which may be related to inhibition of nucleus accumbens PICK 1 protein expression .关键词
EGCG/蛋白激酶C相互作用蛋白1/可卡因/自发活动Key words
EGCG/PICK1/Cocaine/Locomotor activity分类
医药卫生引用本文复制引用
蔡飞,李彩蓉,袁鑫,王江华,蔡雪洲..EGCG通过 PICK1抑制可卡因小鼠的自发活动机制研究[J].湖北科技学院学报（医学版）,2013,(6):461-462,2.基金项目
国家自然科学基金（81000576，31000249）资助 （）
