摘要
Abstract
Objective To study the safety and efficacy of targeted drugs and interventional treatment of congenital heart disease and severe pulmonary hypertension .Methods The clinical data and experience in 23 patients with congenital heart disease and severe pulmonary hypertension ( PAH-CHD ) were reviewed from March 2008 to June 2012 .Results In all 23 patients ,19 cases were PDA ,1 case was ASD ,2 cases were PDA and ASD , 1 case was PDA and the VSD .14 cases were successfully occluded ,and 9 inoperable patients .Compared with the level before operation , femoral arterial oxygen saturation was higher ( P<0.01 ) , and pulmonary artery systolic pressure was lower(P<0.01),the aortic pressure was higher(P>0.05).No deaths after average(38.3 ±20.9) months follow-up.13 patients in 14 operable cases were found to have no postoperative PAH ,and 6 minutes walk test distance was higher ( P<0.05 ) .In 9 inoperable patients ,the pulmonary artery systolic pressure was lower ( P>0.05 ) , 6 minutes walk test distance was higher ( P <0.05 ) .Conclusion Targeting therapy and interventional treatment for congenital heart disease with severe pulmonary hypertension are safe and effective .关键词
心脏缺损,先天性/高血压,肺性/放射学,介入性/靶向药物Key words
Heart defects, congenital/Hypertension, pulmonary/Radiology, interventional/Targeted therapy分类
医药卫生
