心血管外科杂志（电子版）Issue(1)：29-34,6.
经导管封堵未闭卵圆孔对缺血性脑血管事件预防效果的 Meta 分析
Efficacy of transcatheter closure in preventing the recurrence of ischemic cerebrovascular events in patients ;with patent foramen ovale:a meta-analysis
黄丹 1陈柏荣 1肖宏凯 1刘茂 1林岫芳1
作者信息
- 1. 519000 广东珠海，中山大学附属第五医院心血管内科
- 折叠
摘要
Abstract
Objective To evaluate the efficacy of transcatheter closure in preventing the recurrence of ischemic cerebrovascular events in patients with patent foramen ovale ( PFO).Methods Studies comparing the efficiency of transcatheter closure and medical therapy were searched from Pubmed ,EMBASE,Cochrane Library, CKNI and WanFang Digital Journal Database .The pooled effects were measured by weighted odds ratio ( OR ) and 95%confidence interval(CI).All statistical tests were performed with RevMan5.1 software.Results A total of 11 articles were included .Compared with control group ,transcatheter closure therapy may decrease the risk of recurrent ischemic stroke [ OR=0.47 ,95% CI ( 0.32 ,0.70 ) , P=0.0002 ] and composite end points [ OR=0.66 ,95% CI (0.46,0.95),P =0.02].There were no statistical difference in the comparison of recurrent transient ischemic attack [OR=0.67,95%CI(0.31,1.45),P=0.31]and all-cause death[OR=0.81,95% CI(0.41,1.62),P=0.55 ] .Conclusions In the cryptogenic stroke patients with PFO , transcatheter closure is superior to medical therapy for the prevention of recurrent ischemic stroke .Large scale randomized controlled clinical trials are required to determine its long-term efficacy and safety .关键词
卵圆孔,未闭/卒中/封堵治疗/Meta分析Key words
Foramen ovale ,patent/Stroke/Transcatheter closure/Meta-analysis分类
医药卫生引用本文复制引用
黄丹,陈柏荣,肖宏凯,刘茂,林岫芳..经导管封堵未闭卵圆孔对缺血性脑血管事件预防效果的 Meta 分析[J].心血管外科杂志（电子版）,2014,(1):29-34,6.
