新医学Issue(12)：849-853,5.DOI:10.3969/g.issn.0253-9802.2013.12.013
Ki-67在乳腺浸润性导管癌中的表达及其临床意义
Expressions of Ki-67 in breast invasive ductal carcinoma and its clinical significance
黄泽楠 1曾维根 2萨诺杰 1陈健宁 3胡攀 1黄勇1
作者信息
- 1. 510630 广州，中山大学附属第三医院乳腺外科
- 2. 100021 北京，北京协和医学院，中国医学科学院肿瘤医院腹部外科
- 3. 510630 广州，中山大学附属第三医院病理科
- 折叠
摘要
Abstract
Objective To explore the expression of Ki-67 and the relationship between Ki-67 and the clinicopathological parameters of breast invasive ductal carcinoma. Methods Expression of Ki-67 in 362 cases of breast invasive ductal carcinoma patients was assessed by immunohistochemistry,and the correlation between Ki-67 and the clinicopathological parameters were statistically analyzed. Results Fifty-nine point seven per-cent (21 6/362 )of the patients were Ki-67 positive. Ki-67 was positively related to lager tumor size (P<0.05),and it also showed positive correlations with lymph node metastasis,higher tumor grade,vascular tumor emboli,human epidermal growth factor receptor-2,epidermal growth factor receptor and TopoisomeraseⅡ-α(P<0.01 );Ki-67 showed negative correlations with estrogen receptor and progesterone receptor (P<0.01 ). Ki-67 had no correlation with P53 and TNM stage (P>0.05 ). Conclusions Expression of Ki-67 shows correlations with most of the clinicopathological parameters of breast invasive ductal carcinoma,which may be an indicator to predict prognosis of breast invasive ductal carcinoma.关键词
Ki-67/乳腺浸润性导管癌/免疫组织化学方法/预后Key words
Ki-67/Breast invasive ductal carcinoma/Immunohistochemistry/Prognosis引用本文复制引用
黄泽楠,曾维根,萨诺杰,陈健宁,胡攀,黄勇..Ki-67在乳腺浸润性导管癌中的表达及其临床意义[J].新医学,2013,(12):849-853,5.
