新医学Issue(1)：49-52,4.DOI:10.3969/g.issn.0253-9802.2014.01.013
感染性喉炎和痉挛性喉炎患儿血清中IL-4、IFN-γ和IgE水平检测的临床意义
Clinical significance of IL-4,IFN-γand IgE in children with acute infectious laryngitis and in children with spasmodic laryngitis
薛国昌 1任明星 1周静月 1沈琳娜 1宋月娟 1夏欢 1曹丽1
作者信息
- 1. 214062 无锡，苏州大学附属无锡市第九人民医院儿科
- 折叠
摘要
Abstract
Objective To investigate clinical significance and the change of serum IL-4,IFN-γand IgE levels and their clinical significance in children with acute infectious laryngitis and in children with spas-modic laryngitis. Methods Serum samples were obtained from 26 children with acute infectious laryngitis, 31 children with spasmodic laryngitis and 25 healthy children. The change of serum IL-4,IFN-γand IgE levels were observed detected by ELISA in serum when hospital admission (acute stage)were observed.Aand before discharge (convalescent stage). ELISA was used to determine the levels of serum IL-4,IFN-γin serum. Serum IgE level was determined with enzyme-linked fluoroimmuneassay. Results The levels of IL-4 and IgE in chil-dren with acute infectious laryngitis and in children with spasmodic laryngitis in acute stage were much higher than that in control group (P ! 0.05 ). IgE level in children with acute infectious laryngitis were much lower than that in patients with spasmodic laryngitis (P ! 0.05 ). IL-4 and IgE levels in children with acute infec-tious laryngitis and in children with spasmodic laryngitis in convalescent stage were much lower than these in a-cute stage (P ! 0.05 ). IgE level in patients with acute infectious laryngitis in acute stage was lower than that in patients with spasmodic laryngitis (P ! 0.05 ). The levels of IgE in children with acute infectious laryngitis in convalescent stage was lower than that in patients with spasmodic laryngitis (P ! 0.05 ). The levels of IFN-γin children with acute infectious laryngitis and in children with spasmodic laryngitis in acute stage were much lower than that in control group (P ! 0.05 ). IFN-γlevels in children with acute infectious laryngitis and in children with spasmodic laryngitis in convalescent stage were much higher than these in acute stage (P ! 0.05 ). Conclusion There is immunologic disorder in infants with infectious laryngitis and in infants with spasmodic laryngitis. IL-4,IFN-γand IgE might play important role in immunologic pathogenesis. Testing the level of IgE may be valuable in different diagnosis of acute infectious laryngitis and spasmodic laryngitis.关键词
感染性喉炎/痉挛性喉炎/白细胞介素-4/干扰素-γ/免疫球蛋白EKey words
Acute infectious laryngitis/Spasmodic laryngitis/Interleukin-4/Interferon-γ/Immunoglobulin E引用本文复制引用
薛国昌,任明星,周静月,沈琳娜,宋月娟,夏欢,曹丽..感染性喉炎和痉挛性喉炎患儿血清中IL-4、IFN-γ和IgE水平检测的临床意义[J].新医学,2014,(1):49-52,4.
