新医学Issue(3)：169-172,4.DOI:10.3969/g.issn.0253-9802.2014.03.007
阿托伐他汀对射血分数保留心力衰竭患者YKL-40及心功能的影响
Influence of atorvastatin on the YKL-40 and cardiac function in patients with heart failure with pre-served ejection fraction
郭文玉 1王小庆 2徐验 3邹春霞 3杨碧芳 3余丹青3
作者信息
- 1. 510000 广州，南方医学大学
- 2. 518000 深圳，深圳市孙逸仙心血管医院心内科
- 3. 518000 深圳，深圳市孙逸仙心血管医院心内科
- 折叠
摘要
Abstract
Objective To evaluate the influence of atorvastatin on serum chitinase-3-like protein-1 (YKL-40)and cardiac function in patients with heart failure with preserved ejection fraction,and investigate the effect of YKL-40 in the diagnosis of HFPEF. Methods Serum YKL-40,serum lipid and 6-minute walk test (6MWT)were measured at baseline in both healthy control group (n=35)and patients with HFPEF (n=70). 70 patients with HFPEF were randomly assigned to control group who received routine therapy,and atorvastatin treatment group who received routine therapy and additional atorvastatin (20 mg/d). Serum YKL-40,lipid profiles and 6MWT were measured after 1 2-month treatment. Results The levels of YKL-40 were significantly higher in patients with HFPEF than healthy control group (P<0.05 ),the level of serum YKL-40 was strong negatively related with 6MWT (rs =-0.999,P<0.05). After 1 2 months treatment,the YKL-40 level in atorvastatin group is significantly reduced than control group (P<0.05 ),and 6 MWT also showed significant better than control group (P<0.05 ). Conclusion Atorvastatin can improve cardiac function and reduce YKL-40 level in patients with HEPEF. YKL-40 could be a prognostic biomarker in patients with HF-PEF.关键词
阿托伐他汀/射血分数保留心力衰竭/YKL-40/心功能Key words
Atorvastatin/Heart failure with preserved ejection fraction/YKL-40/Cardiac function引用本文复制引用
郭文玉,王小庆,徐验,邹春霞,杨碧芳,余丹青..阿托伐他汀对射血分数保留心力衰竭患者YKL-40及心功能的影响[J].新医学,2014,(3):169-172,4.
